Báo cáo y học: "Utility of the Framingham risk score to predict the presence of coronary atherosclerosis in patients with rheumatoid arthritis" pps
Báo cáo y học: "Utility of the Framingham risk score to predict the presence of coronary atherosclerosis in patients with rheumatoid arthritis" pps
... examined the hypothesis that the Framingham score is increased and associated with coronary- artery atherosclerosis in patients with RA. The Framingham score and the 10-year cardiovascular risk ... in the Framingham risk score in patients and controls, and the majority of the SLE patients with coronary calcification had a low 10-year risk according to the Framingham calculations [12]. In ... 6Research articleUtility of the Framingham risk score to predict the presence of coronary atherosclerosis in patients with rheumatoid arthritisCecilia P Chung1, Annette Oeser1, Ingrid Avalos1,...
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Báo cáo y học: "Effect of adalimumab on neutrophil function in patients with rheumatoid arthritis" pps
... cells. The second aim of the study was to determine whetherdownregulation of phagocyte activities are involved in the anti-inflammatory activity of anti-TNF-α therapy. The lack of activity on ... observed in patients during adalimu-mab therapy does not explain the decreased influx of neu-trophils into synovial joints previously observed in RA patients during anti-TNF-α therapy [14,15]. ... andmay provide an insight into a new and interesting mecha-nism of action of anti-TNF-α mAbs in the control of inflam-matory arthritis.Competing interests The author(s) declare that they have...
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Báo cáo y học: "DAS28: a useful instrument to monitor infliximab treatment in patients with rheumatoid arthritis" pps
... activity to study the validity of the Disease Activity Score and the DAS28. In a study performed in Italy in the late 1990s, it wasfound that the Disease Activity Score was the best measure to discriminate ... best the physician’s clinical judgement of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients underinfliximab treatment. Arthritis Res Ther ... found in this waywere only slightly different from the established cut-off pointsfor the DAS28, which can therefore be regarded asconfirmation. The second interesting finding from Vander Cruyssen...
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Báo cáo y học: "Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis" pps
... regardless of the etiology of such inadequacy. In contrast, vitamin B6 supplementation wasineffective in suppressing inflammatory cytokine production, orreducing ESR, plasma CRP or rheumatoid factor ... measured to examine the impact of pyridoxine treatment on vitamin B6 excretion in these patients. Pro-inflammatory cytokine (TNF-α and IL-6) production, C-reactive protein levels and the erythrocyte ... supplementation in these patients. Post-tryptophan load XA excretion above 146.2 µmol/day (30mg/day) was considered as the cutoff for inadequacy in healthy volunteers after ingestion of 5 g of L-tryptophan...
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Báo cáo y học: "Enhanced reactivity to pain in patients with rheumatoid arthritis" ppsx
... pro-inflammatory responses to painfulstimulation may play a deleterious role in shaping the long-termsymptomatology of RA.Competing interests The authors declare that they have no competing interests.Authors' ... stressors on the physiology and symptomatology of patients with RA. Collectively, laboratory research has docu-mented a maladaptively pro-inflammatory response to stressamong RA patients, with elevated ... involved the study of pain, the most commonly reported and most impairingstressor in RA [10]. The experience of pain is generally asso-ciated with enhanced release of pro-inflammatory cytokines,which...
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Báo cáo y học: "Utility of routine chest radiographs in a medical–surgical intensive care unit: a quality assurance survey"
... incorporation of information from the clinicalexamination reduces the utility of routine CXRs, with only3.4% leading to a change in management. The majority of the changes (78%) were related to repositioning ... radiography in a respiratory intensive careunit. Chest 1985, 88:691-696.6. Silverstein DS, Livingston DH, Elcavage J, Kovar L, Kelly KM: The utility of routine daily chest radiography in the surgical ... probably overestimates the utility of routine CXRsowing to the introduction of selection bias, since the houses-taff decide which patients have morning CXRs. In contrast, the percentage of non-routine...
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Báo cáo y học: " Laugh Yourself into a Healthier Person: A Cross Cultural Analysis of the Effects of Varying Levels of Laughter on Health"
... published by the University of Toronto Press. Prior, he was a student of psychology specialist at the University of Toronto, being awarded an academic scholarship from the University of Toronto. ... history can be obtained by asking the indi-vidual “how many times do you laugh during your regular day?” and have the individual rate their level on a scale of one to ten. Furthermore, other ... According to the survey, level two was considered to be in the range of ten to twenty-five laughs in one day, and on the situational laughter scale, a rating of four to seven. Clinically, laughter...
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Báo cáo Y học: Baboon cytochrome P450 17a-hydroxylase/17,20-lyase (CYP17) Characterization of the adrenal microsomal and cloned enzymes docx
... alignments with bacterial cytochromesP450 has identified domains in the primary sequence of human CYP17 which are involved in the catalytic activity of the enzyme, i.e. substrate docking and binding, the ... conversion of PREG to DHEA, however, appears to differ with respect to the interaction of the enzyme with the 17-hydroxylated intermediate. Baboon CYP17 initiallyconverted most of the PREG to 17-OHPREG ... subsequent hydroxylation bycytochrome P450 21-hydroxylase (CYP21). It is, however,possible for the 17a-hydroxylated intermediate to remainbound to the enzyme or for the released product to rebind...
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Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx
... regulation of a range of components of the translational machinery, principally by changes in theirphosphorylation, leading to modulation of their activities ortheir abilities to interact with one ... recycling of eIF2 to thisform [29,30]. The activity of eIF2B can be modulated in avariety of ways [29,31] including by its own phosphoryla-tion, and through phosphorylation of the a subunit of ... likely therefore that these stress conditionsintervene in different ways to regulate these target proteins,and that they probably do so by modulating the activities of the poorly understood...
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Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx
... only partially soluble in five of the constructsresulting in very poor yields. Intriguingly, in the sixth con-struct, the yield of soluble fusion protein with an extendedcarboxyl terminus of ... solubility of fusion proteins is not necessarily indicative of either properfolding or of increased solubility of the protein of interest.We propose that the success of fusion protein systemsshould ... proteins by maltodextrin affinity chromatographyaccording to manufacturer’s instructions. All constructsshowed equivalent levels of protein induction but the resulting fusion protein had varying...
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