Báo cáo y học: "Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis" potx
Báo cáo y học: "Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis" potx
... profiles in rheumatoid fibroblast-likesynoviocytes induced by the proinflammatory cytokines inter-leukin-1 beta and tumour necrosis factor. Inflamm Res 2005,54:10-16.42. Zhou A, Scoggin S, Gaynor ... blocking agent (infliximab) are lacking in rheumatoid arthritis, we have used gene profiling in peripheral blood mononuclear cells to predict a good versus poor response to infliximab. Thirty three ... Membrane-type 1 matrix metalloprotein cytoplasmic tail binding protein 1MTCBP-1 2p25.2 -2.04 0.005148134 RP1-29K1 containing KiAA0426 NS0.002127203 CytP450, family 4, subfamily F, polypeptide 12 CYP4F12...
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Báo cáo y học: "Gene profiling for defining targets for new therapeutics in autoimmune diseases" potx
... understanding of autoimmune diseases usingmolecular profiling. I will focus on the gene expressionanalysis of T lymphocytes, the key players in severalinflammatory diseases, and on the microarray ... factor family to be differentiallyexpressed in type 1 and type 2 cells. TRAF4 wasexpressed at a higher level in type 1 cells while TRAF5was preferentially expressed in type 2 cells. Members ... phenotype. In a subsequent study, Chtanova et al. used high-densityoligonucleotide microarrays to analyze gene expression in murine CD4+Th1 and Th2 cells, as well as CD8+type 1and type 2 T cells...
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Báo cáo y học: "A functional variant of Fcγ receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies" doc
... conceived the study. HZ per-formed FcγR genotyping and coordinated the statistical analy-sis. YM, TY and YK performed GPI ELISA. TH participated in clinical assessment. TS participated in the full ... modulation – by the lowaffinity genotype of FcγRs – of the bypass between immunecomplex and FcγR bearing cells. In a GPI immunized mousemodel severe arthritis occurred only in DBA/1 mice, ... results do not indicate that individual polymorphisms in the FCGR3A and FCGR2A genes play roles in susceptibilityto RA. Despite the lack of association with individual FCGRpolymorphisms in the whole...
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Báo cáo y học: "Intrapleural instillation of autologous blood for persistent air leak in spontaneous pneumothoraxis it as effective as it is safe" pps
... advan-tages and drawbacks. From tetracycline and doxycycline,to quinacrine, bleomycin, talc, interferon or even silvernitrate [13-16]. Despite the fact that many surgeonsseek the best method of ... immediately introduced into the chest tube.Results: A success rate of 27% was observed having the air leak sealed in 4 patients in less than 24 hours.Conclusion: Despite our disappointingly poor ... with patients of high morbidity andmortality surgical risks who are ineligible for surgery.Conclusively blood pleurodesis is an “only-win” methodas there are minimal complications related to...
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Báo cáo y học: "HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis" potx
... medical history, clinical features, physicalexamination, laboratory data (including tests for rheumatoid factor and antinuclear antibodies) and radiographs. Peripheraland axial joints were evaluated ... main haplo-types found in normal and spondylitic patients in Spanish andJewish populations [13]. Indeed, the spondylitic form of PsAwas found in association with the HLA-B27/Cw1 haplotype in a ... addition, some HLAB27/Cwancestral haplotypes may explain why some HLA-Cw antigensare over-represented in spondyloarthropathies, including PsA.According to this, the HLA-B*2705/Cw*0102, B*2705/Cw*02022...
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Báo cáo y học: "Development of a health care utilisation data-based index for rheumatoid arthritis severity: a preliminary study" ppt
... purposes)Table 1 Rheumatoid arthritis medical records-based index of severitySub-scale Points1. Surgery sub-scale:C1–C2 fusion 3 pointsAny hand joint 1 pointAny foot joint 1 pointMajor joints (hips, ... pointPulmonary nodule 1 pointMaximum score for category: 1 point4. Clinical status sub-scale:Arthritis flares1 1 point2 to 4 2 points5 + 3 pointsWorst physician global rating: "doing ... 450 K 1 pointMaximum score for category: 2 pointsSummary score for primary index Maximum 15 points6. Optional medication sub-scale:Any of the following medications: hydroxychloroquine, gold,...
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Báo cáo y học: "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation" pps
... donor lymphocytes, only veryfew cells were found in joints during the first week oftransfer, and a second cell transfer was needed to inducea significant influx of lymphocytes into the joints ... adaptive immunity cells (representedby donor BALB/c lymphocytes) and cells of innateimmunity (represented by non-lymphoid cells in the recipi-Figure 5Hierarchical clustering (left) and expression ... severe combined immunodeficient mice by usingadoptive transfer of lymphocytes from proteoglycan-immunizedarthritic BALB/c mice. In this unique system only proteoglycan-specific lymphocytes are...
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Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc
... overexpressed at baseline in poor responders are induced by several cytokines in FLSs,thereby suggesting a role for these cytokines in the resistanceto TNF blockade in RA.ANOVA: analysis of variance; ... thereby preventing disease progression in these patients and saving unnecessary costs.TNF antagonists interfere with many pathways involved in RAsynovial inflammatory processes; these include local ... baseline depending on response to therapy, weperformed immunostaining experiments on the synovial biopsyspecimens obtained from the 25 patients included in thestudy. We evaluated the synovial...
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Báo cáo y học: " Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression"
... immunoglobulin chains were also found to be significantly increased in aged thymocytes. Understanding the changes in gene expression in thymocytes with age may hold the key in determining thymocyte ... containing a T7 RNA polymerase promoter. Then cRNA was synthesized using T7 RNA poly-merase which simultaneously incorporates cyanine 3- or cyanine 5- labeled CTP (Perkin Elmer, Wellesley, MA). ... These genes thus may be a contrib-uting factor to the increase in B cells, both in total number and in maturity, within the thymus. The increase in B cell numbers in the thymus with age seems...
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Báo cáo Y học: Dietary bisphenol A prevents ovarian degeneration and bone loss in female mice lacking the aromatase gene (Cyp19 ) pptx
... MolecularCloning. A Laboratory Manual, 2nd edn. Cold Spring HarborLaboratory press, Cold Spring Harbor, NY.25. Hogan, B., Beddington, R., Costantini, F. & Lacy, E. (1994) Tailbleeding. In Manipulating ... xenoestrogens in the ovaries of ArKOmice in vivo.Estrogen plays an important role not only in thereproductive system but also in the regulation of bonemetabolism to maintain bone mass. In the present ... (D)were fixed and stained with hematoxylin &eosin for histological analysis. Decreases in thethickness of the endometrial and myometrialcell layers in ArKO mice were prevented bythe diet supplemented...
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