... proteins. In additionto having a direct impact on HIV infectivity, many ofthese factors also mediate innate immunomodulatoryactivity and consequently have the potential to impactinnate and ada ptive ... MJ, Pandrea I, Faye A, Onanga R, Apetrei C, Poaty-Mavoungou V, Rouquet P, Estaquier J, Mortara L, et al: Antiinflammatoryprofiles during primary SIV infection in African green monkeys areassociated ... prophylactic po tential, and hold great promise as a novel therapeutic approach. The major challenge aheadlies in determining how these potentially importantgoals m ay be safely realized to yield novel...