... 46 9–4 74.8. Murakami, Y. , Matsufuji, S., Kameji, T., Hayashi, S., Igarashi,K., Tamura, T., Tanaka, K. & Ichihara, A. (1992) Ornithinedecarboxylase is degraded by the 26S proteasome withoutubiquitination. ... cellular polyamine levels. A key proteinsuch as antizyme can not function as an effective r egulatorunless it is rapidly degraded or its activity is tightlymodulated.Rapid degradation of antizyme ... (1994)Feedback repression of polyamine transport is mediated by anti-zyme in mammalian tissue-culture cells. Biochem. J. 299, 1 9–2 2.18. Suzuki,T.,He ,Y. ,Kashiwagi,K.,Murakami ,Y. ,Hayashi,S.&Igarashi,...