Báo cáo y học: "The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes" ppt

... and nitric oxide by hSFs and hACs: effects of IL-1F8 and IL-1 Production of IL-6, IL-8 and nitric oxide by hSFs and hACs: effects of IL-1F8 and IL-1 . Shown is an analysis of the effects of IL-1F8 ... articleThe new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytesDavid Magne1*, Gaby Palmer1*, Jenny L Barton3, ... present study (500–5,000 ng/ml).Figure 4Kinetics of IL-1 and IL-1F8 mRNA production by HSFs and hCAs in response to IL-1 and/ or TNF-αKinetics of IL-1 and IL-1F8 mRNA production by HSFs and hCAs...

... 239.7http://genomebiology.com/2009/10/9/239 Rajasekharan and Kennedy: Genome Biology 2009, 10:23927. Livesey FJ, Hunt SP: Netrin and netrin receptor expression in the embryonic mammalian nervous system suggests ... are transmembrane proteins with an extracellular Figure 1The netrin family of proteins. (a) Netrins are members of the laminin superfamily. A phylogenetic tree based on human protein sequences ... (c)(a)Laminin-b2Laminin-b1Laminin-b4Laminin-b3Laminin-a1Laminin-a2Laminin-a3Laminin-a5Laminin-g3Laminin-g1 Netrin- 4 Netrin- G2 Netrin- G1 Netrin- 1 Netrin- 3CVIVVVIIVVIVVC 239.3http://genomebiology.com/2009/10/9/239 Rajasekharan and Kennedy: Genome Biology 2009, 10:239domain...

... mRNAExportmachineryExportmachinery5′ 3′ 5′ 3′ SR SR SR SR SR ALY/REFALY/REF SR SR SR ESE m7GSF2/ASFAAAAAAAAmTOR4EBPPP(a)(b)Pre-mRNA4EBPeIF4E eIF4E http://genomebiology.com/2009/10/10/242 ... 35U2AF65 SR protein Py AGU1 snRNP70K SR protein Exon 1 Exon 2 AU1 snRNPPyU2AF 35U2AF65AG70KU4/U6ãU5tri-snRNP100K27KU2 snRNPExon U2AF 35U2AF65 SR protein Py AG(c)Figure 6 SR protein ... of SR proteins. SR proteins may have two exon-independent functions. SR proteins facilitate splice-site pairing by simultaneously interacting with U1 snRNP and U2AF across the intron. SR proteins...

... 5:20http://www.cardiothoracicsurgery.org/content/5/1/20Page 4 of 7 RESEARC H ARTIC LE Open AccessThe need for intra aortic balloon pump support following open heart surgery: risk analysis and outcomeHaralabos Parissis1*, Michael ... theemergency group & also the two patients operated onunder salvaging conditions. Intra- operatively intraaortic balloon pump support Intra- operatively, ninety patients (66.2%) neededintraaortic balloon ... aortic balloon pump support following open heart surgery: risk analysis and outcome.Journal of Cardiothoracic Surgery 2010 5:20.Submit your next manuscript to BioMed Central and take full advantage...

... fibrosis is increased in CAT2-deficientmice as measured by the whole lung hydroxyproline assay[8]. Interestingly, this baseline fibrosis is not evident his-tologically by trichrome staining, ... would be involved in lung fibrosis.This is based on the following: 1) CAT2 is upregulated in bleomycin -induced pulmonary fibrosis [19] and 2) argi-nase metabolizes arginine to ornithine, which ... 9Conclusions In summary, we have described a pathway (involvingCAT2 and arginine homeostasis) not previously exam-ined in the context of lung inflammation and fibrosis. Wefind that while CAT2 is highly...

... since the attack, people still talk aboutfunerals and memorials that they have attended, cars thatremained parked at train stations for several days, and officesdestroyed and people displaced. ... route had a clear view of the Manhattan skyline, a ghastly caricature of its former glory. The air also bore an acrid flavor as smokecovered much of the sky like an eerie cloud.Reflections and ... meltedinto an emotional blur, fueled by the local and national newsdescriptions, along with the personal uncertainties of loca-tions of loved ones, families, and barely comprehending the carnage before...

... properly cited.Research The RNA binding protein HuR does not interact directly with HIV-1 reverse transcriptase and does not affect reverse transcription in vitroJinwoo Ahn1, In- Ja L Byeon1, ... NusA -HuR binds a synthetic RNA template that contains AREs (Fig. 2C), indicatingthat the fusion does not interfere with the RNA binding activity of HuR. Probing the interaction between HIV-1 RT and ... article as: Ahn et al., The RNA binding protein HuR does not inter-act directly with HIV-1 reverse transcriptase and does not affect reverse tran-scription in vitro Retrovirology 2010, 7:40 Ahn...

... 160:224-235.36. Iwahashi J, Kawasaki I, Kohara Y, Gengyo-Ando K, Mitani S, Ohshima Y, Hamada N, Hara K, Kashiwagi T, Toyoda T: Caenorhabditiselegans reticulon interacts with RME-1 during embryogene-sis. ... factor betaPIX. J CellBiochem 2006, 99:1203-1215.41. Wakana Y, Koyama S, Nakajima K, Hatsuzawa K, Nagahama M, TaniK, Hauri HP, Melancon P, Tagaya M: Reticulon 3 is involved inmembrane trafficking ... protein remains a possible candidate drug target for the disease.Lastly, RTN4 may have a role in multiple sclerosis andhereditary spastic paraplegia. Autoantibodies against the isoform A- specific...

... mostly pop-ulated by immigrants now - from Vietnam. That simple factsays more than any churchyard sermon on the ultimate futil-ity of war.Of course, that war is stupid doesn’t in any way diminish ... guises should teach us: youare what you do.http://genomebiology.com/2008/9/5/105 GenomeBBiioollooggyy2008, Volume 9, Issue 5, Article 105 Petsko 105.3Genome BBiioollooggyy 2008, 99::105 ... people the way he often has between fields ofinquiry; he is inclusionary rather than divisive. Whetheryou agree with him or not, his approach is uplifiting.Science is under siege today as it has...

... ooff tthhee AAIIDD//AAPPOOBBEECC ffaammiillyy ooff ppoollyynnuucclleeoottiiddee((ddeeooxxyy))ccyyttiiddiinnee ddeeaammiinnaasseess pprreeddiicctteedd bbyy ccoommppuuttaattiioonnaall aannaallyyssiiss ... Petersen-Mahrt SK, Neuberger MS: EEvvoo lluuttiioonn ooff tthhee AAIIDD//AAPPOOBBEECC ffaammiillyy ooff ppoollyynnuucclleeoottiiddee ((ddeeooxxyy))ccyyttiiddiinneeddeeaammiinnaasseess Mol Biol Evol2005, ... a crystal structure for a functionallycharacterized AID/APOBEC was not available and many of the structural features of this protein family have beenascertained by comparing their primary and...

... [45-48].Functions of MAP4 and non-neuronal functions of MAP2 and Tau The widely expressed non-neuronal member of the MAP2/Tau family, MAP4, shares many features with othermembers of the family, including ... researchinteractionsinformationrefereed researchProtein family reviewThe MAP2/Tau family of microtubule-associated proteinsLeif Dehmelt and Shelley HalpainAddress: Department of Cell Biology, The Scripps Research Institute ... is regulated bysensory-driven neural activity; the function of this phospho-rylation is not yet known, however [73]. The regulation of MAPs, including the MAP2/Tau family, has been summa-rized...

... and evolutionary history The AP-2 family of transcription factors (Ensembl Family ENSF00000001105) consists in humans and mice of fivemembers, AP-2 , AP-2 , AP-2 , AP-2 and AP-2 ; frogs andfish ... sapiens AP-2 αP. troglodytes AP-2 *M. musculus AP-2 R. norvegicus AP-2 G. gallus AP-2 X. laevis AP-2 X. tropicalis AP-2 D. rerio AP-2 D. rerio AP-2 G. gallus AP-2 P. troglodytes AP-2 *R. ... genome assembly database[5] suggests that there are orthologs of AP-2 ␣, AP-2 ␤, AP-2 ␥and AP-2 ⑀but not AP-2 ␦genes in bony fish, although onlyorthologs of AP-2 ␣ and AP-2 ␤have been...

... Bellotto M,Beachy PA, Basler K: SSkkiinnnnyy hheeddggeehhoogg,, aann aaccyyllttrraannssffeerraassee rreeqquuiirreeddffoorr ppaallmmiittooyyllaattiioonn aanndd aaccttiivviittyy ooff tthhee hheeddggeehhoogg ... aanndd bbeeyyoonndd:: tthhee ooxxyysstteerrooll hhyyppootthheessiiss rreevviissiitteedd aanndd rreevviisseedd Prog Lipid Res 2008, doi:10.1016/j.plipres.2008.04.002.69. Javitt NB: OOxxyysstteerroollss:: ... 8866:21-34.23. Hall TMT, Porter JA, Beachy PA, Leahy DJ: AA ppootteennttiiaall ccaattaallyyttiicc ssiitteerreevveeaalleedd bbyy tthhee 11 77 ÅÅ ccrryyssttaall ssttrruuccttuurree ooff tthhee...