... Phosphorylation of Ser158, which is immediately downstream of theLRR domain, could, for instance, induce a conforma-tional change of the adjacent region, which could berequired for Atx1 binding.Finally, ... the molecular bases of polyQ disease proteins, we report here a study of thestructural determinants for the interactions of Anp32awith other partners. As a prerequisite for binding stud-ies, ... react to aplethora of signals [9–12]. The N-terminal LRRKeywordsataxin 1; leucine-rich repeats; NMR; PP2Ainhibitor; structureCorrespondenceA. Pastore, National Institute for MedicalResearch,...