... activation.PolyP can amplify coagulation by activation of the contact factor pathway, as well as activation of factor V, inhibition of the anticoagulant function of tissue factor pathway inhibitor (TFPI), and ... polyphosphate, the platelet-derived material was a weak activator of FSAP. Hence, negativelycharged polymers with a high charge-to-size ratio are responsible for the activation of FSAP, and also act as ... charge than unfrac-tionated heparin, and exhibits a stronger ability tobind to and activate FSAP [25].Chondroitin sulfate, dermatan sulfate and polysialicacid also have a less negative charge...