Báo cáo y học: "Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow" doc
Báo cáo y học: "Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow" doc
... sIL-1R, increasing the binding affinity of IL-1α and IL-1β to type II sIL-1R byapproximately 100-fold, while leaving unaltered the lowbinding affinity of IL-1Ra to type II sIL-1R, thus enhancinginhibition ... arebroader and include activating or increasing the level of factors able to inhibit proinflammatory cytokines or othercatabolic factors.Interleukin-1βFor specific inhibition of the production/activity ... approaches to improving treatment of OA. The first section reviews the mostReviewMost recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrowJean-Pierre...
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Tài liệu Báo cáo khoa học: Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis doc
... preferable to placing all the genesinvolved in the pathway in the same operon; the cellcan then respond quickly to changes in the environ-ment by changing the expression of only a few genes and using ... phosphoenolpyruvate to pyruvate,is encoded by the second gene in the las operon (Fig. 1). In order to obtain strains with increased PK activity anadditional copy of the pyk gene was recombined into the ... minor flux to mixedacids via pyruvate formate lyase (PFL) [10]. In this study, the activities of PFK and PK weremodulated individually by changing expression of the Keywordsglycolysis; Lactococcus;...
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Báo cáo khoa học: Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle ppt
... responses to ATP were potentiated by cADPR, suggesting that the two adenine nucleotides may work in synergy to maintain the restingtone of the bladder. In conclusion, extracellular cADPR enhances the spontaneous ... conversion of NGD into cGDPR to determine the GDP-ribosyl cyclase activity ⁄ ADP-ribosylcyclase activity, as described previously [51]; this avoided the in uence of cADPR hydrolysis to ADPR. Tissues ... exogenous cADPR failed to increase the spontaneous release of ATP in the absence of CD38. In other words, the presence of CD38 is mandatoryfor the occurrence of intracellular actions of extracellu-lar...
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Báo cáo khoa học: Cyclosporin A-induced oxidative stress is not the consequence of an increase in mitochondrial membrane potential doc
... staining of P-glycoproteinCytospins of GLC4 and GLC4 ⁄ P-glycoprotein cells wereincubated for 1 min with hematoxylin for staining of nuclei. To assess the localization of P-glycoprotein expres-sion ... N-[4-[6-[(acetyloxy)methoxy]-2,7-dichloro-3-oxo-3H-xanthen-9-yl]-2-[2-[2-[bis[2-[(acetyloxy)methoxy]-2-oxyethyl]amino]-5-methylphenoxy]ethoxy]phenyl]-N-[2-[(acetyloxy)methoxy]-2-oxyethyl]-(acetyloxy)methyl ester; GLC4,human small cell carcinoma; ... inhibitcalcineurin. Together, these results suggest that neithermitochondria, inhibition of calcineurin nor blockage of P-glycoprotein play a role in the comparable induction of ROS production by CsA and...
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Báo cáo Y học: A single charged surface residue modifies the activity of ikitoxin, a beta-type Na+ channel toxin from Parabuthus transvaalicus doc
... Gly23 of birtoxin (Fig. 4). In ikitoxin the presence of Glu23 chargepreceding the a-helix modifies the activity of this toxin in aunique way to result in reduced potency in mice. The C-termini of ... homology to known toxins(Fig. 4), birtoxin and ikitoxin are expected to bind to voltage-gated Na+channels. This possibility was examinedby measuring the effect of these toxins on the whole-cellNa+current ... effect and toxin binding sites on the channel. Site 3, or alpha, toxins bind to the S3–S4 loop of domain IV and slow the decay of whole-cell current. Site 4,or beta, toxins are proposed to bind to...
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Báo cáo y học: "Computerized two-lead resting ECG analysis for the detection of coronary artery stenosis" pps
... CAD to determine the level of disease or quantifying the patient’s myocardial ischemic burden at the time of the testing. Resting ECG analysis, including that of the 12-lead ECG, typically ... modeling is used in the analysis of complex systems and the interactions of internal and external environments with those systems. In the case of the heart, analysis is performed on the signals ... and an associated severity score. History and Development of 3DMP Research into the theoretical models underlying 3DMP began in 1976 in the People’s Republic of China in a project that investigated...
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Báo cáo y học: " Computerized two-lead resting ECG analysis for the detection of coronary artery stenosis after coronary revascularization" doc
... factors. Finally, 3DMP was compared in this study to angiography but not to any other non-invasive diagnostic technology. Therefore, inference about the potential superiority or inferiority of 3DMP ... than 5 years prior to inclusion in the study), • Obesity (BMI > 30 kg/m2), • Family history (symptomatic CAD of one parent), • Other risk factors, including established diagnosis of peripheral ... represent the diagnostic endpoint against which 3DMP was tested. Statistical methods An independent study monitor verified the double-blindness of the study and the data integrity and monitored the...
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Báo cáo y học: "Monoclonal Antibodies against Nucleophosmin Mutants: Potentials for the Detection of Acute Myeloid Leukemia" ppt
... of cytoplasmic dislocation of NPM1 by IHC has been performed using aspecific antibodies that bind both the NPM-wt and NPM-mA proteins. In IHC assay labeling with this kind of mAbs, the cyto-plasmic ... were cloned into the BamH I and Hind III site of the pET-32a plasmids creating fusion vectors pET-32a-NPM-mA in the presence of T4 DNA Ligase (TaKara, Tokyo, Japan). The fusion vectors were ... alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry. Blood. 2002; 99: 409-26. 17. Falini B, Mecucci C, Tiacci E, et al. Cytoplasmic nucleophosmin in acute...
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Báo cáo khoa học: "Androgen receptor status predicts response to chemotherapy, not risk of breast cancer in Indian women" doc
... genotypes in a cohort of women with breast cancer and to determine the influence of AR on response to neoadjuvant chemotherapy and clinical outcome.Materials and methods: Genotyping of the AR CAG ... receptor family of ligand-activated transcriptionfactors. The role of androgens and androgen receptors in breast carcinogenesis is poorly understood, althoughwide spread expression of AR in breast ... According to one line of action, the translocation of Bax to mitochon-dria is one of the key steps for Bax-mediated a poptosis[32,33] and AR is required for UV to induce the translo-cation of...
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Báo cáo y học: "A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages" docx
... irreversible inhibition by selectively and rapidlyacetylating a serine residue (Ser 530) near the C-terminus of the cyclooxygenase (COX) family of enzymes, formingan impediment to the binding of arachidonic ... Bertsche T: An in- vitro screening assay for the detection of inhibitors of proinflammatory cytokine syn-thesis: a useful tool for the development of new antiarthritic and disease modifying drugs. ... macrophages and monocytes. Cytokines arepolypeptide or glycoprotein factors that act in an auto-crine and/ or paracrine fashion to signal in a variety of bio-logical processes. They are generally considered...
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