... with the expression of mRNAs for nuclear factor (NF )κB1 mRNA in bone marrow CD34+ cellsThe relevance of treatment with the expression of mRNAs for nuclear
factor (NF )κB1 mRNA in bone marrow CD34+ ... NFκB1 mRNA expression parallels the elevation of
NFκB1 protein expression in bone marrow CD34+ cells. The
protein expressio...
... groups, indicating that the
increase of these infiltrating T cells may be responsible for
the low number of macrophages in lung. These results
indicate that the development of tissue injury in MRL/lpr
mice ... recruitment of specific inflammatory cells into the
lung during pulmonary inflammation in lupus-prone mice. In
contrast to the findings of other invest...
... on the array for miR-494 have 12 predicted tar-
get genes in common. These 12 target genes were a na-
lyzed using Ingenuity Pathway Analysis software
(Ingenuity Systems, Inc., Redwood City, CA, ... down-regulated at the transcriptional level and are
inversely correlated with the expression of the miRNA
in the same corresponding samples. Our analysis
yielded putative target...
... in one but not all of the other mouse models.
The expression of these miRNAs, therefore, may be
relate d to the initiatin g oncogenic event and may poten-
tially contribute to mammary tumor initiat ... Met-mediated invasive growth of cells [43].
miR-150 has been shown to negatively regulate the
expression of the Myb oncogene [44]. These findings
suggest that the lo...
... expression profiling of human
erythrocyte could be an important key for under-
standing the machinery of anucleate protein synthesis
and its meaning in the pathophysiology of diseases.
Acknowledgements ... in human RBCs encoding initiation, activation
and regulation of transcription and translation (for
instance RNA polymerises I,II,III, zinc/PHD finger-
DNA-binding...
... the findings obtained by
hematoxylin and eosin staining. We examined the expres-
sion of these proteins in a cancer-free layer of squamous
epithelial cells, carcinoma in situ (CIS) and invasive ... 2)
to gain insight into the correlation between the expression of
Mcm4 and the cell cycle. In both cells, clear nuclear staining
was observed with anti-Mcm4 Ig. Although...
... of
cystatin F is hypothetical. Although most cystatins inhi-
biting cathepsin L also inhibit cathepsin S, an inhibitory
activity of cystatin F against cathepsin S has not yet been
reported.
The ... unusually high for a
secreted cystatin ( 25% of the cystatin F in 2- or 4-day
culture medium). By contrast, U937 cells contained only
3–4% of the related inhibitor, cystatin C....
... liver. Furthermore, we investigated the
speci®city of the human CBG with r espect to the glycone
and aglycone moieties, and in particular characterized the
ef®ciency of the enzyme in hydrolysing a ... 2002
20 lL of the enzyme/inhibitor mixture to 180 lLof
substrate (4NPGlc), incubating for 30 min at 37 °C, and
measuring the rel ease of 4NP.
Protein assays and prote...
... that encode the
multisubunit protein. We show that the majority of clones
resulting from the fusion inherit the expression levels of the
parental cells, thus simplifying screening for clones with
stochiometric ... mL of 50% poly(ethylene glycol) 1500
(Boehringer Mannheim, Germany) was mixed with the cells
over a period of 1 min, under continuous stirring with a
pipe...
... allowing the interaction of
Antarctic b-tubulin isotypes with CCT in the adverse
energetic conditions of the Antarctic habitat. The role of
these amino acid substitutions in the folding process of
E. ... 2002
differences in the affinity of CCT for b-T1 and b5 folding
intermediates. Alternatively, this may be due to the differ-
ences in the primary structures...