Báo cáo y học: "Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis" pps
Báo cáo y học: "Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis" pps
... and in vivo studiesshowed that methotrexate is ineffective in the presence of antagonists of adenosine or adenosine deaminase (theenzyme responsible for the deamination of adenosine to inos-ine) ... the anti-inflammatory effects of methotrexate and adenosine are mediated by different receptors in different inflammatory loci, an observation that may explainwhy inflammatory diseases of some ... anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppres-sion of activation and adhesion molecules. Clin Immunol 2005,114:154-163.13. Cronstein BN: Low-dose...
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Báo cáo y học: "Suppression of nitric oxide production from nasal fibroblasts by metabolized clarithromycin in vitro" potx
... treatment of airwayinflammatory diseases, since M-4 does not show anyantimicrobial activity [17].NO is primarily derived from a cationic amino acid,L-arginine, and oxygen by a family of NOS. ... subjects.Assay for inducible NO synthases (iNOS)The iNOS levels in cytosol were assayed by commer-cially available human iNOS ELISA kits (R & D Systems,Inc., Minneapolis , MN) that contained sufficientreagents, ... inhibition of inflammatory cytokine produc-tion and polymorphonuclear leukocyte activation, mayaccount for the clinical effectiveness of macrolides in inflammatory airway diseases [1,3-6,8]. Recently,...
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Báo cáo y học: "Suppression of nitric oxide production from nasal fibroblasts by metabolized clarithromycin in vitro" pptx
... treatment of airwayinflammatory diseases, since M-4 does not show anyantimicrobial activity [17].NO is primarily derived from a cationic amino acid,L-arginine, and oxygen by a family of NOS. ... subjects.Assay for inducible NO synthases (iNOS)The iNOS levels in cytosol were assayed by commer-cially available human iNOS ELISA kits (R & D Systems,Inc., Minneapolis , MN) that contained sufficientreagents, ... fibroblasts may be one of the mechanisms leading to the favorable modificat ion of airway inflammation as a res ult of macrolide therapy. It is reported that after oral administration of CAM intohuman,...
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Báo cáo Y học: Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin potx
... Shore, V.G., Fielding,P.E. & Egelrud, T. (1973) Cofactor activity of protein components of human very low density lipoproteins in the hydrolysis of tri-glycerides by lipoproteins lipase from ... The morphology of thefibrils appeared indistinguishable to that of fibrils formed in the absence of clusterin [6]. Distinctive features of clusterinalone were not visible at the nominal magnification(·40 ... stability of apoC-II in the absence of lipid is typical of lipid-freeapolipoproteins and may underlie the general propensity of apolipoproteins to form amyloid in vivo [7]. The ability of apoC-II...
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Báo cáo y học: ": Suppression of neutrophil accumulation in mice by cutaneous application of geranium essential oi" doc
... 6.Results Inflammation of the skin by curdlan intradermal injectionSkin inflammatory response induced by intradermalyinjected curdlan (0.5 mg/50 µl), was investigated first by using two parameters, ... application of essential oils on the accumulation of neutrophils in inflammatory sites in skin of mice.Methods: Inflammation with accumulation of inflammatory cells was induced by injection of curdlan, ... administered intraperitoneallyor cutaneously on the inflammation induced by curdlanintradermal injection were examined.At first, geranium oil was injected intraperitoneally tomice. Prednisolone...
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Báo cáo Y học: Regulation of stress-activated protein kinase signaling pathways by protein phosphatases pot
... phosphorylation of conserved tyrosine and threonine residues within thecatalytic domain. This phosphorylation is mediated by dualspecificity protein kinases, members of the MAPK kinase(MKK) family. ... systems.REGULATION OF SAPK SIGNALPATHWAYS BY PROTEINPHOSPHATASES IN YEAST CELLSA molecular g enetic analysis of ye ast cells indicated that twodistinct protein phosphatase groups, protein ... [35,37,40,43–45]. In addition, activation of p38 but not ERK o r JNKenhances MKP-1 induction in H4IIE hepatoma cells [36]. In Rat1 fibroblasts, MKP-1 is induced by Ca2+signaling,independently of MAPK activation...
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Báo cáo Y học: Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition ppt
... a serine peptidase characterized by oligopeptidaseactivity. It is grouped in family S9A in clan SC [1]. Enzymesbelonging to clan SC are distinct from trypsin-type andsubtilisin-type serine ... in phenotype.Fig. 1. Western-blot analysis of PEP expression in established antisensecell lines. The PEP activity remaining in each antisense cell line cor-responds to the signal intensity ... Auerswald, E.A. (1995) Temporary inhibition of papain by hairpin loop mutants of chicken cystatin. Distortedbinding of the loops results in cleavage of the Gly(9)-Ala10 bond.FEBS Lett. 361,...
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Báo cáo y học: " Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes" ppsx
... chemotaxis andproinflammatory cytokine synthesis [36]. Interestingly, it alsocauses hyperesthesia, including by local injection into rodentpaws, and mice lacking the PROK receptor PKR1 have dimin-ished ... dimin-ished pain responses [37]. It is therefore intriguing to specu-late that PROK-2 contributes to the symptoms of MSU crystal inflammation by enhancing both inflammation and pain in affected ... point as the peak of a rapid, early surge in proinflam-matory cytokine and immediate early gene transcription. In agreement with the induction of IL-6 mRNA in the mem-brane, analysis by enzyme-linked...
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Báo cáo y học: "Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation: therapeutic implications" doc
... carriers is the currentparadigm for bone induction in the clinical setting [9]. Thepotential of inhibiting the inhibitors is therefore of greatinterest, because a single inhibitor - such as noggin ... of the role played by chordin in osteogenesis.The authors demonstrated successful knockdown of chordinexpression by small-interfering RNA transfection of humanMSCs cultured in an osteogenic ... sclerostin. Theyshowed that combining noggin and sclerostin at a specificconcentration resulted in a single complex, neutralizing theirrespective inhibitory effects. This allowed BMP signalling...
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Báo cáo y học: "Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir" pptx
... with an increased incidence of myocardial infarction. The pathophysiological mechanism is unknown. In this study markers of inflammation and coagulation in HIV-infected patients using antiretroviral ... in HIV-1-infected individuals receiving combination antiretroviral therapy. HIV Med 2009, 10:627-33.11. Libby P, Ridker PM: Inflammation and atherosclerosis: role of C-reactive protein in ... factor in the process of endothelial dysfunction, but has not been studied in thissetting. Anti-angiogenic properties through an inhibitoryeffect on VEGF were attributed to protease inhibitors in glioblastoma...
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