Báo cáo y học: "Most nuclear systemic autoantigens are extre

Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps

... immune system is further amplified by the results of the analysis of MHC II T cell epitopes using the ProPred server shown in Fig. 5b. Here we can see that the extremely disordered regions of the virus ... extremely disordered proteins. Thus X-ray studies of extremely disordered proteins tend either to focus on the ordered domains of the proteins that c...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: "Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis" ppsx

... sample are indicated by a spot, with the intensity of the spot representing the proportion of significantly differentially expressed transcripts for each one of the transcriptional modules. The ... before. The 37 classifiers discriminated training set samples analyzed using the novel data with 100% accuracy as before, despite the change of microarray platform. (...

Ngày tải lên : 09/08/2014, 20:20

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Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt

... followed the kinetics of amylose synthesis over a 5-day period of nitrogen starvation and measured the amounts of starch, amylose, the k max of the starch fractions, the degree of crystallinity and the ... is synthesized in vivo when the rate of amylopectin synthesis becomes minimal. At these moments the rates of amylopectin synthesis are only 5% of their m...

Ngày tải lên : 22/02/2014, 07:20

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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx

... a heme covalently attached to the polypeptide chain via two thioether bonds, formed from the vinyl groups of the heme and the two cysteine residues in the consensus Cys-X-X- Cys-His motif [1–4]. ... proteins in the native state are stabilized by 10– 20 kJÆmol )1 compared with those in the denatured state; the energy is equivalent to the formation of only a few hydrogen...

Ngày tải lên : 24/03/2014, 03:21

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Báo cáo y học: "κ Increased AP-1 and NF-κB activation and recruitment with the β combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocyte" ppt

... inflammatory disease characterized by the infiltration of the synovial membrane with monocytes/T cells, by the proliferation of synovial lining cells and by the production of proinflammatory cytokines, which ... Conversely, in RA synoviocytes, we found a higher effect of the combination of IL-17 with IL-1β than with TNF-α. The strongest effect was observed for the co...

Ngày tải lên : 09/08/2014, 01:23

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Báo cáo y học: "THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis" pps

... initiate the inflammatory process and are the source of many cytokines responsible for cartilage and bone loss, this may be a primary mechanism by which THR0921 provides clinical benefit. The effect of ... were analyzed for each condition. Data are pre- sented as the percentage of the cells cultured with medium alone. The results are displayed as the mean ± stand...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: " High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease." docx

... on the dynamics of these molecules inside the cell and the diversity of activities that these molecules display once they are outside. Competing interests The authors declare that they have no ... system to tissue damage and to trigger an immediate response. A key facet of the biology of alarmins is therefore their translocation from the inside to the outside of the...

Ngày tải lên : 09/08/2014, 10:23

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Báo cáo y học: "Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration" pptx

... http://arthritis-research.com/content/10/4/R86 Page 7 of 8 (page number not for citation purposes) humans [36]. Efficient clearance of the dying cells, whether they have died by apoptosis or autophagy, is advantageous. If they are not cleared, ... terms of number of particles, they ingest more than the monocyte/macrophage cells, possibly due to their greater size. The fact t...

Ngày tải lên : 09/08/2014, 10:23

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Báo cáo y học: " Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats" pps

... microinjection of the test agent into NTS. The BRR response was represented by the ratio of the peak magnitude of reflex bradycardia to the peak magnitude of phenylephrine-induced pressor response. The averaged ... The averaged value of BRR response obtained from three injections of phenylephrine prior to microinjection of the test agent served as the baselin...

Ngày tải lên : 10/08/2014, 05:21

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Báo cáo y học: " Non infective severe aortic paravalvular leakage 7 years after surgery: the role of suture technique" pot

... suturing of the aortic annulus and sew- ing ring of the artificial valve prior to lower the prosthe- sis. Then a gentle alternate traction on the three semicontinuous sutures, usually with the help of ... asymptomatic paraprosthetic jets are often detected incidentally as a result of high sensitivity colo r flow mapping [8]. These small leaks are at short term usually be...

Ngày tải lên : 10/08/2014, 09:21

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