Báo cáo y học: "Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis" ppsx
... 6
Research article
Polymorphism in the tumour necrosis factor receptor II gene is
associated with circulating levels of soluble tumour necrosis
factor receptors in rheumatoid arthritis
John R Glossop, ... associated with a protective
role in familial RA [30].
In this study we report that polymorphism in the TNF-RII gene,
but not the TN...
... further identify
amino acid side chains involved in the docking of
cytochrome c, or in the presumed electron entry from
cytochrome c to the Cu
A
center. Positions subjected to
mutagenesis in this ... complex of the
respiratory chains of mitochondria and many bacteria
[1–4]. It catalyzes the reduction of oxygen to water, coupling
the free energy of this reaction to...
... This raises the possibility that any one or a
combination of these properties may in uence the binding
of apolipoproteins to lipoprotein particles. The capacity to
fractionate lipid emulsions into ... [13,16]. ApoE3 is the
most common isoform and is associated with normolipide-
mia [13,17], while the apoE4 isoform is independently
associated with an increased risk...
... (chronic
hyperplastic rhinosinusitis) but without polypo-
sis and those patients with diffuse sinonasal
polyposis with polyps projecting into or com-
pletely occluding the nasal airway (CRS with
polyposis). ... impact of this new technology has been,
theoretically, to increase the safety and com-
pleteness of surgery in addition to increasing the
confidence of the surgeo...
... proteins. It is a complex cascade
involving proteolytic cleavage of serum glycoproteins
often activated by cell receptors. This cascade ultimately
results in induction of the antibody responses, inflam-
mation, ... and
reproduction in any medium, provided the original work is properly cited.
of native C3, res ulting into binding of factor B, which is
cleaved by facto...
... provided
new insights into how OA may be successfully managed.
The symptoms of osteoarthritis: pain and
instability
The pain of OA is activity-related, with pain coming on
generally only when a person ... the
synovium, in ligaments especially near their insertions, in bone,
in muscle, and in the outer third of the meniscus in the knee. In
an unusual study in...
... 1
Composite indices are the best depicters of
disease activity. The degree of disease activity
at the start of a disease-modifying therapy is a
major determinant of the disease activity
attainable in ... proinflam-
matory cytokine interleukin-6 (IL-6) and the observation that
CRP levels over time correlate with joint damage [10,21]
indirectly link joint damage to th...
... Calin, of Bath, UK, had started this
kind of work in the early 90s with the definition of the Bath
Ankylosing Spondylitis Disease Activity Index (BASDAI) [21],
the Bath Ankylosing Spondylitis ... probably will be
published early in 2009. In these criteria, sacroiliitis detected
either by x-rays or by MRI will play a dominant role. The exact
diagnostic value of active...
... cellular localisation. Pyrin
is thought to interact with a variety of proteins within the
cytoplasm and to play a key role in the modulation of
inflammation and apoptosis [11]. Many of its interactions
appear ... TNF, tumour necrosis
factor; TNFR1, tumour necrosis factor receptor 1; TNFRSF1A, tumour necrosis factor receptor superfamily 1A; TRAPS, tumour...
... members of the HIF family in the pathogenesis of SSc
has not yet been investigated in detail.
Insufficient response to hypoxia: dysregulation
of angiogenesis in systemic sclerosis
Angiogenesis and ... Angiogenesis and vasculogenesis
in systemic sclerosis. Rheumatology (Oxford) 2006, 45(suppl
3):iii26-iii27.
52. Varga J, Bashey RI: Regulation of connective tissue synthesis...