Báo cáo y học: "Somatic mutations in mitochondria: the chicken or the egg" docx

... osteoarthritis (OA). Moreimportantly, in RA tissue significantly more of these mutations resulted in non-synonymous amino acid changes than those in tissues of patients with OA. Mutations in mtDNA have ... mtDNA mutations actually provokepathological states or should they be consideredepiphenomena? In other words, why do somatic mtDNA mutations increase, and what consequences might theyhave? ... have a role in the pathogenesis of various diseases. The ‘classic’ mito-chondrial syndromes like Leigh syndrome or Leber’s hereditaryoptic neuropathy are caused by inherited (germline)mutations...

Báo cáo y học: "Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes" ppt

... University Health Network, Toronto, Ontario, Canada3Department of Medicine, University of Toronto, Mount Sinai Hospital, Toronto, Ontario, CanadaCorresponding author: Tanya R Da Sylva, dasylva@yorku.caReceived: ... in RA.Competing interests The author(s) declare that they have no competing interests.Authors' contributionsTD participated in the design of the study, performed some of the molecular ... p53 is randomlymutated during chronic inflammation by oxygen radicals. Cer-tain mutations within p53 then confer a survival advantage to the synoviocytes, giving them 'transformed'...

Báo cáo y học: "Biological therapy in early arthritis – overtreatment or the way to go" pptx

... currently the first line oftherapy in early inflammatory disease; however, with the availability of more effective (but more expensive) agents, arewe justified in now using these at the onset ... combination group, but by only 25% in the monotherapy groups. The results of these studies show that TNF-blocking drugs,used either in combination or as monotherapy, have a morerapid clinical ... blockadetherapyIdentifying patients who benefit the most from TNF-blockingtherapy is a reasonable strategy for optimising the use ofthese drugs. This includes determining factors for poorprognosis in patients...

Báo cáo y học: "Sinus aspergilloma in rheumatoid arthritis before or during tumor necrosis factor-alpha antagonist therapy" ppsx

... fungusgrowing in a cavity, in the lung or a sinus, often a maxillarysinus. Aspergilloma has been found in 3.7% of patients under-going surgery for chronic inflammatory sinusitis [12].Sinus aspergilloma ... imaging wasperformed [10]. In our study, CT of the sinuses was performedonly to investigate symptoms. Sinus aspergilloma may remainasymptomatic for several years, however, and may thereforebe underestimated.Sinus ... carried out in the PubMed data-base, using the following keywords: (rheumatoid arthritis OR ankylosing spondylitis OR spondylarthritis) AND (aspergilloma OR fungus ball OR aspergillosis OR sinusitis)....

Báo cáo y học: "Somatic structural rearrangements in genetically engineered mouse mammary tumors" pptx

... with the highest mapping qualityretained. Further, erroneous mapping of reads originat-ing from D NA present in sequence gaps in NCBI buildm37 assembly were removed by excluding the highlyrepetitive ... Wesequenced the remaining Trp53 allele in these tumorsbutwereunabletoidentifyanysomaticmutationsresulting in a loss of heterozygosity. The features of the Varela et al. Genome Biology 2010, 11:R100http://genomebiology.com/2010/11/10/R100Page ... dri-ver mutations is complicated by the intrinsicheterogeneity in the genetic background of humanpopulations, and therefore in the profile of somatic mutations that may arise. Analysis of cancers...

Báo cáo y học: " Regional coordination in medical emergencies and major incidents; plan, execute and teach"

... be included in the riskassessment regarding possible major incidents in thisregion. The purpose of this study was to find whether thisinstitution has achieved its primary tasks by analyzing ... a senior surgeon or anesthesiolo-gist with training in disaster medicine) was created. In this24/7 system, the RTiB is the POC for the healthcare facili-ties within the region and has the mandate ... emergencyresponse pre-planning as well as psychosocial support, the workload could mainly be handled during normaloffice hours.Training, Exercises and EducationDuring the period of study 28...

Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"

... factors for DM. Neither treatment-emergentweight gain nor treatment group significantly impacted the risk for TED. Established risk factors for diabetesinclude: family history, ethnicity, increasing ... Angiotensin Converting Enzyme CYP = Cytochrome P450 + Not all agents are appropriate for monotherapy. Inclusion in this table does not necessarily imply efficacy. * Currently FDA approved for use in ... portacaval shunting, thereby decreasing first passmetabolism; decrease in quantities and affinity of plasmaproteins, thereby increasing free-drug levels; increase in volume of distribution in...

Báo cáo y học: "Technical Considerations in Decompressive Craniectomy in the Treatment of Traumatic Brain Injury"

... using temporal fascia is similar to the one introduced by Yu et al.32 They separated the temporal deep fascia from the temporal muscle to the zygomatic arch, and then cut the fascia from the ... along th e zygoma but left the fascia base 1-2 cm long for the blood supply. Finally, they turned the temporal fascia beneath the temporal muscle and sutured it to the dura. They performed this ... supporting the portion of brain run in the artificial “vascular tunnel” between the brain tissue and dura. Finally, the dura wa s cl os ed as i n augmen-tation duraplasty. In the latest report,...

Báo cáo y học: "Pathogenic organisms in hip joint infections"

... quickly and efficiently, and increasing mortality, high economic burden for removal of in- fected joint prosthesis and implant renewing [17] al-ways require the increased effort in sampling and ... by examination of typical laboratory medicine and mi-crobiology characteristics in joint fluid. In addition to the macroscopic parameters (e.g. color, viscosity) the gram stain is the fastest ... only moderate. For initial therapy in the presence of clustered gram posi-tive cocci in microscopic examination and, therefore, most likely an infection with S. aureus is the intrave-nous therapy...

Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"

... common polymorphisms in DNA repair genes are continuously being identified, and these polymorphisms may play a pivotal role in sporadic carcinogenesis. A growing body of literature, including observations ... results. The Lys751Gln polymorphism has been more studied than the Asp312Asn polymorphism, because the frequency of the 751Gln allele is more prevalent than the 312Asn allele. The Asp312Asn polymorphism ... are important for maintaining DNA integrity and preventing carcinogenesis. Recent lung cancer studies have focused on identifying the effects of single nucleotide polymorphisms (SNPs) in candidate...

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