... (HAQ) to assess functional ability [9]. The radiological damage was assessed in X-ray scans of the handsand wrists biannually (2000, 2002, and 2004), which wereread centrally by a trained radiologist ... LEF,sulfasalazine cyclosporine A, aTNF and others), the followingcovariates were also analyzed: age at disease onset, age atbaseline, gender, years of disease duration, presence of comorbidity (hypertension, ... The baseline DAS28-3 was associated with a signifi-cant progression of DAS28-3 and Larsen score (Table 2). In addition, extra-articular RA was also associated with higherDAS28-3 values and,...