Báo cáo y học: "Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis" pptx

Báo cáo y học: "Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis" pptx

Báo cáo y học: "Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis" pptx

... but they were not impaired in synovial fluid from RA patients. Our data indicate that NKT cells may be involved in the disease process of RA and that a strategy to boost the regulatory potential ... regulatory potential of NKT cells might represent a useful candidate therapy for RA. Introduction Natural killer T (NKT) cells are a distinct subset of lymphocytes...
Ngày tải lên : 09/08/2014, 06:22
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Báo cáo y học: "CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway" pdf

Báo cáo y học: "CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway" pdf

... surface was not altered by U8 3A treatment, with minimal effects up to an hour, in contrast to stimulation with human chemokines which showed rapid, clathrin mediated internalisation after 5 minutes ... interests The authors declare that they have no competing interests. Authors' contributions JC carried out the binding, internalisation and confocal microscopy studies, and contribut...
Ngày tải lên : 11/08/2014, 08:22
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Báo cáo y học: "Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis" doc

Báo cáo y học: "Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis" doc

... potent ability to inhibit proinflammatory cytokine synthesis, interleukin (IL)-10 has a marginal clinical effect in rheumatoid arthritis (RA) patients. Recent evidence suggests that IL-10 induces ... indicate that IL-10 may contribute to monocyte differentiation into the proinflammatory type of mac- rophages characteristic of RA. It has been shown that IL-10 augments the macrophage col-...
Ngày tải lên : 09/08/2014, 08:22
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Báo cáo y học: " Kennedy Institute of Rheumatology Division, Imperial College London, 12–13 November 2003: Towards a molecular toolkit for studying lymphocyte function in inflammatory arthritis" ppt

Báo cáo y học: " Kennedy Institute of Rheumatology Division, Imperial College London, 12–13 November 2003: Towards a molecular toolkit for studying lymphocyte function in inflammatory arthritis" ppt

... http://arthritis-research.com/content/6/2/55 Introduction Despite many years of study, the aetiology of inflammatory arthritis remains poorly understood. A growing body of data describing leukocyte differentiation, migration and cellular interactions has ... RA demonstrated a defect in the ability of their CD4 + CD25 + T cells to inhibit the production of TNF-α by monocytes. This de...
Ngày tải lên : 09/08/2014, 01:23
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot

Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot

... originate, in the thymus or in the periphery. One prevailing model is that a class of regulatory T cells that originate in the thymus, are self-reactive and are involved in protection from autoimmune ... [10]. In mice, T R cells are thought to represent a population of T cells that are thymically derived and suppress autoreactive CD4 + T cells. This is sup...
Ngày tải lên : 09/08/2014, 01:24
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Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis" pps

Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis" pps

... with a cytostatic drug and administered early in actively induced arthritis. We show that CD134 can be used as a marker for activated auto-aggressive T cells early in AA, that targeting of these ... cells start to infiltrate the joints [17]. The present data therefore suggest that early in AA, CD134 + T cells, after activation in the PLN, can migrate to Figure 4 Anti-CD13...
Ngày tải lên : 09/08/2014, 06:22
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Báo cáo y học: " Transcriptome analysis of functional differentiation between haploid and diploid cells of Emiliania huxleyi, a globally significant photosynthetic calcifying cell" potx

Báo cáo y học: " Transcriptome analysis of functional differentiation between haploid and diploid cells of Emiliania huxleyi, a globally significant photosynthetic calcifying cell" potx

... transcriptomes General features, comparison to existing EST datasets, and analysis of transcriptome complexity and differentiation High quality total RNA was obtained from eight time points in the diel cycle ... spreadsheet indicating the results of automatic queries with C. reinhardtii flagellar-related proteins against E. huxleyi EST clusters, and an analysis of these clusters compared...
Ngày tải lên : 09/08/2014, 20:20
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 Báo cáo y học: " High blood pressure, antihypertensive medication and lung function in a general adult population"

Báo cáo y học: " High blood pressure, antihypertensive medication and lung function in a general adult population"

... detailed analysis of antihypertensive medication indicates that BBL medication and not any other antihypertensive medication is associated with a reduced lung function. This negative effect of ... the data analysis, interpretation of data and manuscript preparation. JH and ES developed the statistical analysis plan. SK, HS, SG, CM, MH, AP, H-EW, JB, RMH and JH assisted in the interpreta...
Ngày tải lên : 25/10/2012, 10:45
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Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx

Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx

... the Rac1 sequence to arginine and analyzed the mutated proteins for ubiquitination in HEK293 cells. Most of the 18 mutations tested did not notably affect the polyubiquitination pattern of myc–Rac1L61 ... persistently activated and associated with plasma membrane, Rac1b has an impaired ability to activate several Rac1 downstream signaling path- ways [27,28]. To evaluate the possible effe...
Ngày tải lên : 18/02/2014, 16:20
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Báo cáo y học: "Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a TH2-dominated respons" potx

Báo cáo y học: "Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a TH2-dominated respons" potx

... releasing T H 2 attracting chemokines and aquire a distinct migratory phenotype. Finally, we could show that in a murine sensitization model, nasal instilla- tion of OVA together with aqueous pollen ... con- stituents. PALMs potently attract and activate PMN and eosinophils The finding that pollen grains interact with cells of the human immune system was made by Siegel and Sherman...
Ngày tải lên : 08/08/2014, 21:20
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