... Huseyinov A, Hatip FB, Cinar MG, Evinc A: Role of leukotrienes on coronary vasoconstriction in isolated hearts of arthritic rats: effect of in vivo treatment with CI-986, a dualinhibitor of cyclooxygenase ... modify FLAP expression.These results indicate that the balance of PGE2 levels in OAosteoblasts is actually driving the expression of LTs, and con-versely that chronic inhibition of COX may ... which is reminiscent of the fact that PGE2inhibits 5-LO activity [55].We showed previously that in OA subchondral osteoblastslong-term treatment with NS-398, a selective COX-2 inhibitor,leads...