Báo cáo y học: "Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy" pps
Báo cáo y học: "Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy" pps
... observed in both the synovial lining layer and the synovial sublining layer, these markers were scoredseparately in the two compartments. An overview of the 15 synovial parameters is given in Table ... significantly associated with disease activity in spondyloar-thropathy (SpA) (lining-layer hyperplasia, inflammatory infiltration, polymorphonuclear cells, sublining CD68, and sublining CD163). ... that lining-layerhyperplasia and infiltration with PMNs and macrophage subsets are directly related to the global disease activity in SpA, we next investigated whether synovial histopathologycould...
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Báo cáo Y học:Association of the thyrotropin receptor with calnexin, calreticulin and BiP Effects on the maturation of the receptor docx
... member of the Hsp70 family and promotes the folding and assembly of protein byrecognizing unfolded polypeptides and inhibiting intra- and intermolecular aggregation [17]. To investigate the role of ... that the maturation of the glycopro-teins synthesized in the endoplasmic reticulum involvesinteractions with molecular chaperones, which promote the folding and assembly of the glycoproteins. In ... CRThave been described as being necessary to the folding and oligomeric assembly of various glycoproteins [17].To study the role of CNX and CRT in the folding of newly synthesized TSHR molecules,...
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Báo cáo y học: " Management of subtrochanteric femur fractures with internal fixation and recombinant human bone morphogenetic protein-7 in a patient with osteopetrosis: a case report" pot
... bearing. At that time, he continued to com-plain of some pain when walking, and discomfort whileinternally and externally rotating his hip. Radiographsdemonstrated the hardware to be intact with ... site. Further investigation of the effectiveness and indications of bone morphogenic protein use for the management of delayed fracture healing in patients with osteopetrosis is warranted.IntroductionOsteopetrosis, ... Due to the extreme bone density of our patient and the lack of a fem-oral canal, the use of an intramedullary device was dis-counted. The procedure proved technically challengingdue to the density...
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Báo cáo Y học: Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development and in adult rat tissues docx
... T.(1980) Role of argininosuccinate synthetase in the regulation of urea synthesis in the rat and argininosuccinate synthetase-asso-ciated metabolic disorders in man. Adv. Enzyme Regul. 18,221–238.20. ... recessive disease caused by aliver-specific deficiency in argininosuccinate synthetase(ASS). In the liver, the AGC plays an important role in the urea cycle by providing aspartate for incorporation intoargininosuccinate ... kidney [6,18] and human kidney cell lines[12,18], therefore it may compensate for the loss of citrin in the kidney of patients with CTLN2. This raises a generalquestion of whether the two isoforms...
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Báo cáo y học: "Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity" ppsx
... Hence,genotyping of all four SNPs was unnecessary and, in the remaining samples, only the putative disease causal polymor-phism was genotyped.None of the SNPs tested was associated with RA using sin-gle-point ... individuals included in the cohortwas not included in the analysis. Of the available samples,genotyping was attempted in 1,600 and was successful in 1,589 in the current study. Of all the controls ... that the associatedpolymorphism controls the levels of gene expression. The association was replicated in the same study in another cohort of RA patients, with systemic lupus erythematosus and...
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Báo cáo y học: " Expansion of the human mitochondrial proteome by intra- and inter-compartmental protein duplication" ppsx
... observed in the case of sulfateassimilation and cysteine biosynthesis found in the chloro-plasts, cytosol and mitochondria of plants [57]. In addition, the evolutionary history of 12 Calvin cycle ... proteome in the ancestor of human and yeast (Figure 4). The growth of the mitochondrial proteome by gene duplicationKnowing the homology of proteins with a determined locali-zation in human and yeast, ... ribosome expandingsignificantly at the root of eukaryotes [49-51]. Interestingly,regulators of activity of the complexes via phosphorylation and dephosphorylation (as for PDH) or deacetylation...
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Báo cáo y học: "Review of "The Twelfth West Coast Retrovirus Meeting" and "The Twenty-third Annual Symposium on Nonhuman Primate Models for AIDS"" doc
... mechanism of action of the most intensely studied peptide revealed the involve-ment of the signalosome as well as the enzyme caseinkinase II in HIV-1 infectivity. These early-stage inhibitorsare ... the seemingly higher stringencyexpected with a high-dose challenge. Other differences,including route and timing of delivery of PMPA, or differ-ences in the challenge viruses themselves (the ... especially if the results could be sub-sequently compared to results in the human.Innate immunityIt is becoming increasingly evident that the innateimmune system plays a critical role in the control...
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Báo cáo y học: "Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis" pdf
... taking aspirin and all cytokine inhibitors 10to 14 days prior to surgery.Histology of synovial biopsies and levels of cytokinesHaematoxylin and eosin histology was performed on 26 of the OA and ... simply reflect the level of synthesis/release and catabolism of endocannabinoids and entourage compounds in the synovium. The source of the endocannabinoids present in the synovium and synovial ... five cells thick with slight increase in cellularity and with few inflam-matory cells; 2 = moderate inflammation: synovial intima fourto six cells thick, with dense cellularity and inflammatory...
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Báo cáo y học: "Use of the measure your medical outcome profile (MYMOP2) and W-BQ12 (Well-Being) outcomes measures to evaluate chiropractic treatment: an observational study"
... correlating with the findings of the SF-36 [1].Based on this and the observational findings of thisstudy, the MYMOP2 has potential as a clinically usefultool to assess chiropractic care in terms of ... objective was to investigate the validity of the MyMOP2 instrument to detect a change in well-being of patients attending the RMIT chiroprac-tic teaching clinic. The mean baseline MYMOP2 profile score ... deliveredby student chiropractors in a clinical teaching facility. The W-BQ12 was also used as a tool to assess the validity of the well being component of the MyMOP2 against the validated W-BQ12 instrument...
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Báo cáo y học: "Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya"
... University School of Medi-cine and Moi Teaching and Referral Hospital (Eldoret,Kenya) and the Institutional Review Board of the IndianaUniversity School of Medicine (Indianapolis, Indiana).Informed ... hugerisks and acted with great bravery to return to the clinic and to obtain their medication refills.▪ Patients really surprised us. They walked distances, theyran away, they tried again, they came ... based in Eldoret,Kenya. BSM is a Data Manager in the Department of Med-icine, Indiana University School of Medicine. PB is anAssistant Professor of Medicine at the Indiana UniversitySchool of...
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