Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
... 1). Role of IL-17 in T cell immunity and/orpropagation of joint inflammation In arthritis, IL-17 is a pro-inflammatory cytokine thought tocontribute to the joint inflammatory process [38]. Studies in ... targetfor the treatment of destructive arthritis. Because it isknown that this T cell factor can have synergistic effectswith catabolic/inflammatory mediators, it is tempting tospeculate that IL-17 ... Anti-IL-17cytokine therapy is of interest as an additional new anti-rheumatic strategy for RA, in particular in situations in which elevated IL-17 might attenuate the response to anti-TNF/anti-IL-1...
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Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf
... cytokines and chemokines that attract leu-kocytes to the site of infection and trigger the maturationand trafficking of antigen presenting cells for induction of adaptive immunity (figure 1). The ... by host pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), elicits innateimmune responses that subsequently instruct adaptive immunity. Recovery from the inciting stimulus ... structural integrity of th e lung epithelium.This barrier is e nhanced by airway goblet cells thatsecrete mucus and ciliated epithelial cells that constantlytransport this viscous layer towards...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... With this in mind, itcould be interesting to investigate whether the accumu-lated T reg cells in patients with arthritis function properly in vivo and whether these patients could really benefit ... might be too late toinhibit activation of effector T cells and their migration to thejoint. Indeed, T- cell activation is an early event in AIAbecause CD4+ T cell depletion ameliorates the ... induction or at later timepoints when indicated.Delayed-type hypersensitivity reactionSeven days after arthritis induction, mice were challengedby intradermal injection into their ears of 5...
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Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
... Forward GTATTCAAAAGTGGTCCCGGACAAAATGAG GACTTGReverse TCCGGGACCACTTTTGAATACTTTCAAGTGCATATATTTATTP74G Forward CAAAAGTCTTGGCGGACAAAATGAGGACTTGGTACReverse CATTTTGTCCGCCAAGACTTTTGAATACTT TCAAGTGCQ76G ... contains threedomains resembling family 2 cystatins.Cystatins competitively inhibit the activity of papain-like cysteine proteases by binding to the active site of thelatter and forming a tight, ... minimally,about twofold, from that of wild-type cystatin A (Table 2).Association rate constantsThe kinetics of association of the cystatin A mutantswith papain, cathepsin L and cathepsin B were analyzedÓ...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... alter the binding mode and affinity of theenzyme for PAA and derivatives thereof, while maintainingthe hydrophobicity of the binding site.To test the effect of the mutations on the specificity ... thephenylalanines in the active site suggesting that hydropho-bic interactions between the aromatic phenylalanines andthe phenyl ring of the substrate play an important role in substrate binding. ... activity asindicated by the low initial rates of PGA conversion. Thisdecrease in activity indicates that the mutations in uencethe rate of acylation by PGA in a similar way as theacylation...
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Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... mutants still bindcoenzyme M and exhibit some activity although in bothmutants the coordination of zinc differs from the situation in the wild-type enzyme. Apparently, other ligands to zinc(H2O ... revealed by the crystal structure [19]. Zincthus can be quite differently coordinated and still activatethiol groups for alkylation. Consistent with the interpreta-tion is our finding that both MtaA ... apparentabsence of any sulfur in the first coordination sphere of Zn in the Cys239 fi Ala mutant suggests that Cys316 is not adirect Zn ligand in MtaA. It would be interesting toinvestigate the...
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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... [12,13]suggest that correct orientation of the penicillin substratewith respect to the putative high-energy ferryl intermediateis important for optimum coupling between 2-oxoglutarateand penicillin ... peni-cillin substrates is a desirable objective, as this may allowfermentation of starting materials for production of semi-synthetic cephem antibiotics. The results in this papersuggest that point ... cosubstrate binding [17]. Stimulation of 2-oxoglutarate conversion is therefore evidence for ÔprimeÕsubstrate binding, but not necessarily of its oxidation.The effects of the DAOCS arginine mutations...
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Báo cáo y học: "The role of Probiotics in allergic diseases" pptx
... others. The type of probi-otic product was different as well as the timing of theintroduction of the probiotic, Taylor et al administeredthe probiotic supplement postnatally, while other studiesadministered ... [21].Probiotics can potentially modulate the toll-like receptorsand the proteoglycan recognition proteins of enterocytes,leading to activation of dendritic cells and a Th1 response.The resulting stimulation ... crucial role in the maturation of the host immune system during the first years of life[4]. In addition to environmental factors, the intestinal floramay be a contributor to allergic disease due to...
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Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc
... of these kinds of prospective study, it is tempting to trans-late animal data to our management of patients. However,before doing this, certain points must be considered.Most of the studies in ... repairprocess.Another point relates to the use of indomethacin in theinhibition of heterotopic ossification in patients who havesustained a pelvic fracture. These patients are at risk fordeveloping heterotopic ... [12]showed that restoration of PGE2levels immediatelyrescues the effects of an absence of COX-2. Thus, with-drawal of the drug in a patient might lead to a restoration of prostaglandin synthesis...
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Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt
... and two transactivating domains, namely theamino-terminal transactivating domain and the carboxyl-terminal transactivating domain (C-TAD). The C-TAD hasbeen shown to interact with co-activators ... (involved in the maintenance of cells in an undifferentiated state), both of which notablycontain ankyrin repeat motifs containing the asparagineresidue hydroxylated by FIH [31]. Another target, ... understanding of the biology of theHIF transcription family may eventually lead to thedevelopment of therapies aimed at interfering with this keysignalling pathway, and hence to modulation of hypoxia-dependent...
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