Báo cáo y học: "The role of statins as potential targets for

Báo cáo y học: "The role of statins as potential targets for bone formation" pptx

... all bone resorption inhibitors, which act mainly to stabilize bone mass by inhibiting the activity of osteoclasts (the cells responsible for bone loss). The ability of these drugs to increase bone ... an Commentary The role of statins as potential targets for bone formation I Ross Garrett 1 and Greg R Mundy 2 1 OsteoScreen, San Antonio, Texas, USA 2 The Institute...

Ngày tải lên : 09/08/2014, 03:24

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Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (steﬁn A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf

... affinity for the other two enzymes. Mutation of Gln76 and Asn77 did not alter the affinity of cystatin A for any of the proteases studied. The decreased affinities were caused exclusively by increased ... loop of cystatin A studied, Gln76 and Asn77, are of minimal importance for the affinity of the inhibitor for the cysteine proteases and therefore presumably do not interact dire...

Ngày tải lên : 17/03/2014, 10:20

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Báo cáo Y học: The role of hydrophobic active-site residues in substrate speciﬁcity and acyl transfer activity of penicillin acylase pdf

... methyl ester or the amide as acyl donor. It appeared that 6-APA and 7-ADCA were able to efﬁciently deacylate the phenylglycyl- and p-hydroxyphe- nylglycyl-enzyme of bF24A, as indicated by, respectively, ... wild-type values, whereas the speciﬁcity con- stants for p-hydroxyphenylglycine amide and phenylglycine amide had decreased 10-fold, due to a decreased k cat value. A low amidase a...

Ngày tải lên : 17/03/2014, 23:20

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Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc

... methionine synthase MetE [15], betaine:homocysteine S-methyltransferase [16], S-methyl- methionine:homocysteine methyltransferase [17], epoxy- alkane:coenzyme M transferase [18] and protein farnesyl transferase ... catalyzes the methylation of coenzyme M with methylcob(III)alamin [9]. Several isoenzymes of MtaA, designated MtbA and MtsA have been found [9–11]. The methylation of coenzym...

Ngày tải lên : 17/03/2014, 23:20

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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

... deacetylcephalosporin C synthase; DAOC, deacetoxycephalosporin C; DAOCS, deacetoxycephalosporin C synthase; Dnase 1, deoxyribonuclease 1; EDTA, ethylenediaminetetraacetic acid; ESI MS, electrospray ... Pharmacy and Pharmacology, The University of Bath, UK Deacetoxycephalosporin C synthase (DAOCS) catalyses the oxidative ring expansion of penicillin N, the committed step in the biosynthesi...

Ngày tải lên : 18/03/2014, 01:20

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Báo cáo y học: "The role of Probiotics in allergic diseases" pptx

... 1 of 7 (page number not for citation purposes) Allergy, Asthma & Clinical Immunology Open Access Review The role of Probiotics in allergic diseases Sonia Michail Address: Department of Gastroenterology ... the development of allergic diseases. As the rise in prevalence of allergic diseases has been seen mostly in industrialized countries, this led investigators to formula...

Ngày tải lên : 08/08/2014, 21:20

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Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc

... Manigrasso MB, O’Connor JP. Cyclo-oxygenase-2 function is essential for bone fracture healing. J Bone Miner Res 2002, 17:963-976. 11. Einhorn TA. Do inhibitors of cyclooxygenase-2 impair bone healing? ... activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892. 7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-infla...

Ngày tải lên : 09/08/2014, 01:21

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Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt

... study the expression and regulation of these enzymes in RA. HIF: role of FIH FIH is an asparaginyl β-hydroxylase, which belongs to the same superfamily of 2-OG and Fe 2+ -dependent dioxygenases as ... existence of new targets other than HIF for prolyl hydroxylation and regulation. A recent report has revealed inhibitor of nuclear factor-κB (IκB) kinase (IKK)-2 to be a target...

Ngày tải lên : 09/08/2014, 01:22

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Báo cáo y học: "The role of osteoprotegerin in arthritis" ppsx

... mg/kg/day Start Onset of symptoms Onset of symptoms Onset of symptoms Duration 7 days 35 days 5 days Effect on inflammation No No No Effect on cartilage damage Yes No Mild a Effect on bone erosion Yes ... observations it was evident that synovial inflammatory tissue has unique invasive prop- erties, which even enable the invasion of bone and, finally, the destruction of bone. T...

Ngày tải lên : 09/08/2014, 01:23

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Báo cáo y học: "The role of structural genes in the pathogenesis of osteoarthritic disorder" potx

... deafness Hypochondrogenesis Kniest dysplasia Osteoarthritis with mild dysplasia Spondyloepiphyseal dysplasia, congenital type Spondyloepiphyseal dysplasia, Namaqualand type Spondyloepiphyseal dysplasia, ... Strudwick type Spondyloepiphyseal dysplasia, various types Spondyloepiphyseal dysplasia with precocious OA Spondyloperipheral dysplasia Stickler syndrome, type I Wagner syndrome 120180 Col...

Ngày tải lên : 09/08/2014, 06:22

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