... meet the variable demands imposed by the intermittent course of
RA. Evidence from animal models convincingly supports the application of gene therapy in RA, and the
feasibility of gene therapy was ... synovial lining
layer in both arthritis models. An alternative approach for
suicide gene therapy is to inhibit cell proliferation. The cell
cycle is contro...
... to
dealing with the range of autoantigens that might be
pathogenic in RA and MS by array technology. They used
253 antigens for their synovial array and 406 for their myelin
array. This, of course, ... further
control not examined was the testing of the CII immunised
mice on the myelin array or vice versa. A controversial finding
in this study was the demonstration of...
... ideal for human germline gene therapy. A major
problem is the relatively low rate of transgene integration: in mice, the overall efficiency of transgenesis
(taking into account embryo loss in ... purpose of this paper is to consider the potential for applying the
available genetic modification (GM) technologies to the goal of achieving human germline gene
th...
... met by
responsible gene therapy protocols using safe vectors. Two
clinical trials exploring the use of gene therapy in OA are
under way and another is in the pipeline. If successful, they
could ... arthritis gene therapy in the refereed
literature. The data are based on a PubMed search using ‘arthritis gene
therapy as the search term. The first paper on...
... and gener-
ally reduced the signs of inflammation. The groundwork for
further studies on the dynamics of lymphocyte interactions
in the synovium has thus been established.
Most of the work in intravital ... leukocyte
and lymphocyte migration in the parenchyma of tissues can
be followed in vivo by imaging in thin tissues like the mesen-
teries or by fluorescen...
... complement-
dependent cellular cytotoxicity of the cells expressing the
cytokine [37]. Furthermore, infliximab has been shown to
increase the number of apoptotic T lymphocytes in the lam-
ina propria [38] and ... and clinical statuses are pre-
sented in Table 1. Patients were followed clinically by the
same physician during this period at regular intervals and in
particu...
... PTPN12, are found among lists of genes that are directly
regulated by the TNFα/NFκB pathway, whether in RA [41] or
in another context [42,43]. Therefore, it is likely that most of
our transcripts are ... and detailed in Table 4. The identity of the corre-
sponding microarray cDNA probes was verified by sequenc-
ing. Finally, we performed an unsupervised hierarchical...
... study, depending
on the way in which productivity is valued, the costs of
infliximab could be compensated for by savings in
productivity [48]. Another study reviewing costs in early
inflammatory ... disease
processes and the prevention of development of further
inflammation [9-11]. DMARDs are currently the first line of
therapy in early inflammatory disease; howe...
... whether they currently smoked and the number of
cigarettes smoked per day. From these reports, we calculated
pack years of smoking (product of years of smoking and packs
of cigarettes per day).
Other ... smokers were
asked for the number of cigarettes typically smoked per day
and former smokers reported the age at which they stopped
smoking and the number of cigarett...
... (LIPC) is a lipolytic enzyme synthesized in
hepatocytes playing a major role in HDL metabolism. It
takes part in hydrolysis of triacylglycerides and phosphol-
ipids of HDL
2
into antiatherogenic, ... we
constructed a risk profile. Carriers of the risk profile were
defined as having one of the following polymorphisms:
hetero- or homozygous for the variants of eNOS 4a...