Báo cáo y học: "Towards in vivo application of RNA interference – new toys, old problems" pdf
Báo cáo y học: "Towards in vivo application of RNA interference – new toys, old problems" pdf
... = RNA- induced silencing protein complex; RNAi = RNA inter-ference; shRNA = small hairpin RNA; siRNA = small interfering RNA. Arthritis Research & Therapy Vol 6 No 2 Rutz and ScheffoldIntroduction In ... its application to functional gene analysis in mammalian cells in vitro and in vivo, and potential therapeutic applications.Technology reviewTowards in vivo application of RNA interference – new ... closely.ConclusionRNAi has rapidly evolved as a potent technology for theanalysis of gene function in many organisms in vitro and in vivo. In mammals, at present RNAi is mainly restricted tothe analysis of...
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Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt
... number of factors, including the longevity of the injectedprotein and the level of free G-actin in the circulation at sites of inflammation inhibiting the DNase I activity. Our dataobtained by a ... activity was mainly measured from urine instead of serum because the absence in urine of natural inhibitors of DNase activity such as G-actin.To test if the expression of DNase I from T cells in ... (ash.DNase I), engineered for three new properties – resistance to inhibition by G-actin, resistance to inhibition byphysiological saline and hyperactivity compared to wild type. Bycrossing these transgenic...
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Báo cáo y học: "Advances in immunomodulating therapy of HBV infection"
... respectively. Interestingly, an increase in virological response over time after the discontinuation of thymosin could be observed (p=0.02) [40]. The doses of thymosin α-1 in this meta-analysis are ... elimination of the virus but is also responsible for liver damage caused by the lytic activity of HBV-specific cytotoxic T lymphocytes (CTL) on HBV-infected hepatocytes and by production of inflammatory ... Low TLK, Goldstein AL. Thymosins: structure, function and therapeutic applications. Thymus 1984; 6: 27-43. 39. Chien RN, Liaw YF, Chen TC, Yeh CT, Sheen IS. Efficacy of thymosin α-1 in patients...
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Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"
... methods (melting curve analysis, line probe assays) lies in their single-base discrimination. Specificity can be influenced by the sequences neighboring a polymorphic site, or by possible interference ... intermediate intermediate yes MALDI-TOF <5% intermediate intermediate No intermediate intermediate intermediate yes DNA arrays na intermediate intermediate no high high low yes Indirect methods ... within a broadening and evolving clinical context. Moreover, it is increasingly apparent that clinically relevant prediction and monitoring of viral resistance may not only require the use of...
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Báo cáo Y học: Synthesis, characterization and application of two nucleoside triphosphate analogues, GTPcNH2 and GTPcF pdf
... labeling of single residues in the protein [38]this may yield detailed insights into the dynamics of thenucleotide binding site.The GTPcF analogue may be particularly usefulbecause of the ... MgCl2solution at 50 mM in a syringedipping into the cell. The two solutions are mixed bycomputer controlled stepwise injections (typically in inter-vals of 4 min) from the syringe which serves ... c-Fluoroadenosine triphosphate.Synthesis, properties, and interaction with myosin and heavymeromyosin. Biochemistry 11, 286 3–2 871.34. Pfeuffer, T. & Eckstein, F. (1976) Topology of the GTP-bindingsite...
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báo cáo hóa học:" An in vivo evaluation of bone response to three implant surfaces using a rabbit intramedullary rod model" doc
... with hydroxyapatite (CHA). The hydro-xyapatite coating was applied by plasma spraying highpurity hydroxyapatite powders with tightly controlledparticle size using Sulzer Metco Plasma Spray System.HA ... present study, as well as in those reportedby others, bone often appears to be directly depositedon the h ydroxyapatite coating without any interveninglayer of fibrous tissue, the latter being more ... implants in a canine femoral model [10,43 ,44]. Aten-year clinical follow up of a hydroxyapatite-coatedfemoral stem did not find evidence of distal osteolysisdespite relatively high polyethylene...
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Báo cáo y học: "Anaphylaxis after Topical Application of Bacitracin: A Case Report Mona Al-Ahmad, Sean Mace, University of Toronto, Toronto, ON" doc
... dependentmanner in the recruitment of inflammatory cells, par-ticularly neutrophils, into the airway.Syk Tyrosine Kinase Participates in 1 IntegrinSignaling and Inflammatory Responses in Airway Epithelial ... in signaling path-ways induced by integrin engagement in airway EC.Syk-mediated signaling regulates IL-6 and ICAM-1expression and may be important in the pathophysiol-ogy of lung inflammation. ... after piercing. The use of bacitracin atsites of inflamed body piercings poses a risk for thedevelopment of anaphylactic sensitivity. A history of bacitracin use should be determined in patients...
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Báo cáo y học: "Hypoxia in the pathogenesis of systemic sclerosis" ppt
... procollagenprolyl hydroxylases (P4HA1 and P4HA2), lysyl oxidase (LOX)and lysyl hydroxylases (procollagen lysyl hydroxylase andprocollagen lysyl hydroxylase 2). Similar links betweenhypoxia and ... physiological regulation of cellular responses to hypoxia.Upregulation of prolyl hydroxylase domainactivity in chronic hypoxiaInterestingly, PHD2 and PHD3 are induced by hypoxia in aHIF-1α-dependent ... oxygen-dependent regu-lation of HIF-1α. This hydroxylation is catalyzed by a family of 2-oxoglutarate dependent dioxygenases called prolyl hydroxy-lase domains (PHDs) [7]. During the hydroxylation...
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Báo cáo khoa học: "Biological in-vivo measurement of dose distribution in patients’ lymphocytes by gamma-H2AX immunofluorescence staining: 3D conformal- vs. step-and-shoot IMRT of the prostate gland" ppsx
... afterirradiation (in- vivo and in- vitro) to allow comparabilitybetween the samples.However, the determination of the p robability of lym-phocytes’ presence in the body tissue is difficult, due tothe lymphocytes’ ... cumulative number of lymphocytes exposed to a certaindose, or more. This visualization of distribution of radiated lymphocytes was defined as dose-lymphocyte-histogram (DLH).The original dose-volume-histograms ... explained b y the possibility of repeateddose exposure of some lymphocytes as explained above.The linear correspondence between induction of gH2AX foci and the delivered dose has already been...
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Báo cáo y học: " Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets" pps
... areconvincingly replicated in independent cohorts. Moreover,although a recent twin study indicated that genetic factorsplay a role in determining the severity of RA [46], theheritability of the ... evaluation of the effect of genetic variation in MMP3 on the level of joint damage in RA is thereforerequired.The increasing comprehension of the role of genetics in disease outcome in RA may promote ... Additionally, erosions often initiallypresent in the small joints of the feet, and appear in the smalljoints of the hands at a later point in the disease course [6].Also, rheumatoid nodules are very...
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