Báo cáo y học: "α Impact of VIP and cAMP on the regulation of TNF-α and IL-10 production: implications for rheumatoid arthritis" pps
Báo cáo y học: "High mobility group box-1 protein as a tumor necrosis factor-independent therapeutic target in rheumatoid arthritis." ppsx
... pannusformation, synovial membrane hypertrophy, and mononuclearcell predominance within synovial tissue [7]. The injection of rHMGB1 results in mild to moderate synovitis and maypersist for at least ... addition, nocorrelation was observed between clinical response and the direction of change of HMGB1 expression. The authorsconcluded that their results reveal an unaffected expression of HMGB1 ... may be problematic given regional variation.Therefore, additional studies are required to further establish the relationship of HMGB1 and TNF in patients with RA. The present study supports the...
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Báo cáo y học: "α Impact of VIP and cAMP on the regulation of TNF-α and IL-10 production: implications for rheumatoid arthritis" pps
... production of TNF-α and IL-10 bymonocytes. Spontaneous production of IL-10 and TNF-α by monocytes could not be detected; cytokine productionwas induced, however, by addition of LPS (controlsamples). ... dibutyryl cAMP, forskolin, and VIP were tested for cytotoxicity and displayed no toxi-city at the concentrations being used in this study asdetermined by (3-[4,5-dimethylhiazol-2-yl]-2,5-diphenylte-trazolium ... concentration of cAMP obtained per condition.Cytokine determination by ELISASandwich ELISAs were used to measure human IL-10, TNF-α, and IFN-γ. In the IL-10 assay, the anti -IL-10 mono-clonal antibody...
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Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
... processesunderlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and conveniently administered therapy for PAHincreases the importance ... astate of progressive chronic organ ischaemia. Dysfunction of cellular components of the arterial wall and dysfunction of inflammatory and haemostatic systems are interrelated(Fig. 1) [3,4]. Endothelial ... cell dysfunction is characterised bydecreased production of the vasodilators nitric oxide and prostacyclin, and by enhanced release of endothelin-1.Endothelial cell dysfunction influences the...
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Báo cáo y học: "Technical Considerations in Decompressive Craniectomy in the Treatment of Traumatic Brain Injury"
... supporting pillars on the bilateral sides of the vessels as they pass the edge of the dural window (the pillars were made of hemostastic sponge wrapped by absorbable thread), and then the superfi-cial ... craniotomy, removal of the in-tracranial lesion, and duraplasty, the bone flap was replaced and one side of the flap was attached to the cranium by plates. The plates act as a hinge that al-lows the ... cra-niectomy for lesions or swelling confined to one ce-rebral hemisphere, and bifrontal craniectomy from the floor of the anterior cranial fossa to the coronal suture to the pterion for diffuse...
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Báo cáo y học: "What do biomarkers tell us about the pathogenesis of ankylosing spondylitis" ppsx
... pathogenesis of ankylosing spondylitis?Walter P MaksymowychDepartment of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2 CanadaCorresponding author: Walter P Maksymowych, walter.maksymowych@ualberta.caSee ... anti-TNF therapy does not prevent the development of new syndesmophytes [10]. On the contrary, it appears that new syndesmophytes are even morelikely to develop at those vertebral corners demonstratingresolution ... activity, and pathogenesis in ankylosingspondylitis. Biomarkers reflecting disease activity (metallo-proteinase-3) and inflammatory lesions on magnetic resonanceimaging predict new bone formation...
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Báo cáo y học: " Chemokine blockade: a new era in the treatment of rheumatoid arthritis" ppsx
... for by other members of the superfamily. In addition, some ligands may be agonists atone receptor and antagonists at others. Another issue isthat one should not interfere with the role played ... is the redundancy of the system, based on in vitro studies. Because onereceptor can usually bind multiple ligands and vice versa,one may anticipate that blockade of one ligand or receptormay ... 90% of the monocytechemotactic activity present in the synovial fluid of the majority of RA patients [30]. In a randomized studypatients with active RA were treated for 2 weeks with ahighly...
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Báo cáo y học: "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity" pdf
... activity by gelatine zymography (Figure 4). The 342FFGVG-G2 and CTX-II peptides are generated by an array of MMPs, of which MMP-2 and MMP-9 are only a subset. On other occasions, the presence of these ... n-telo-peptides of pro-collagen type II under the current culture condition are almost exclusively releasedduring synthesis and thereby may be valid markers for collagentype II formation. These data further ... reference is measured. The intra and inter-assay variations of the assay were 9.6% and 11.2%,respectively.d) Detection of S-GAG The concentration of S-GAG in conditioned medium and car-tilage extracts...
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Báo cáo y học: "AIT test has no problem in the detection of anti-ribosomal P" ppsx
... qualitycontrol program run by the Korean Society of LaboratoryMedicine [3]. In 1999 and 2007, reports of antinuclearantibody test using the IT-1 cell line on 208 and 588systemic lupus erythematosus ... in the pictures they revealed. In addition to the anti-Rib-P that Mahler and colleagues mentioned, limitations of the HEp-2 cell line in the detection of autoantibodies such asanti-Ro have long ... Available online http://arthritis-research.com/content/11/3/407Page 1 of 2(page number not for citation purposes)Mahler and colleagues posed a question on the reliability of the indirect immunofluorescence...
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Báo cáo y học: " AIT test has no problem in the detection of anti-ribosomal P – authors’ response" docx
... systematic study is mandatory to compare the sensitivity and specificity of the AIT test for the detection of anti-Rib-Pantibodies and other antibody specificities using a variety of contemporary diagnostic ... to the anti-Rib-P system, Bonfa and colleagues clearly demonstrated that immunodiffusion hasvery low sensitivity for the detection of anti-Rib-P antibodies[3]. In their study, only 14% of anti-Rib-P-positive ... immuno-assays, therefore, the data presented by Jearn and Kim donot support the claim that the AIT test represents a sensitive and reliable method for the detection of anti-Rib-P antibodies.A systematic...
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Báo cáo y học: "Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells" ppt
... conceived and designed the experiments. LFH QYG GFZ YHHperformed the experiments. LFH participated in the design of the study and performed the statistical analysis. TTW LFH YYH Wrote the paper. ... Pouyssegur J, Pages G: Implication of the ERK pathway on the post-transcriptional regulation of VEGF mRNA stability. MethodsMol Biol 2010, 661:451-469.22. Bi S, Liu JR, Li Y, Wang Q, Liu HK, Yan ... 2A). Then we consideredwhether the culture supernatants could regulate the migration of HUVEC. The Millicell cel l culture insertwas used to study the migration of the HUVEC in vitro. The migration...
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