... demonstrated the super-iority of the MVAC to CISCA and CDDP, respectively,both in ORR, and in OS [13,14]. The MVAC is efficient,but particularly toxic. In the phase II study [11], the com-bination induced ... note that these combinations remain inferior to the standard chemotherapy as was proven by the phaseIII randomized study conducted by the Hellenic Coop-erative Oncology Group comparing docetaxel-cisplatinto ... rapamycin (mTOR) is an intra-cellular serine/t hreo nine protein kinase posit ioned at acentral point in a variety of cellular signaling cascades. The established involvement of mTOR activity in...