Báo cáo y học: "What do biomarkers tell us about the pathogenesis of ankylosing spondylitis" ppsx

... assessed the impact of treatment withadalimumab on serum MMP3, VEGF, and bone specific alka-EditorialWhat do biomarkers tell us about the pathogenesis of ankylosing spondylitis?Walter P MaksymowychDepartment ... inflammatory changes in the spine predict the development of new syndesmophytes,complete resolution of inflammation at a vertebral cornerfollowing the institution of anti-TNF therapy does not ... establishedinflammatory lesion in ankylosing spondylitis.Appel and colleagues [1] have studied the link betweeninflammation, destruction, and repair in ankylosing spondylitis(AS) by analyzing serological biomarkers...

Báo cáo y học: "What epidemiology has told us about risk factors and aetiopathogenesis in rheumatic diseases" doc

... evidencethat the cyclooxygenase-2 enzyme encoded by PTGS2 has arole in the pathogenesis of knee OA [119]. The iodothyronine-deiodinase enzyme type 2 (DIO2) gene hasbeen identified as a new susceptibility ... disease.Systemic lupus erythematosusEnvironmental risk factors The majority of research into environmental risk factors forSLE has focused on the role of hormones due to the higherprevalence of ... naturalmenopause whereas there was little association with currentuse or duration of use of hormonal replacement therapy ororal contraceptive pill and no association with the use of fertility drugs. The...

Báo cáo y học: " Chemokine blockade: a new era in the treatment of rheumatoid arthritis" ppsx

... 90% of the monocytechemotactic activity present in the synovial fluid of the majority of RA patients [30]. In a randomized studypatients with active RA were treated for 2 weeks with ahighly ... pitfalls that could hamper the clinical use of thisapproach. Of particular importance is the redundancy of the system, based on in vitro studies. Because onereceptor can usually bind multiple ligands ... vivo.Despite the availability of multiple highly specificcompounds, species specificity of small molecules andneutralizing antibodies complicates the use of thesecompounds in animal models. Nevertheless,...

Báo cáo y học: "What do measurements of molecular biomarkers in different body fluids really tell us" doc

... respectively), however, suggest ing that they arise primarily systemically, thereby explaining these correlations. If the biomarkers do arise AbstractMolecular or biochemical biomarkers of joint ... helping us understand joint pathology, its detection and treatment. But they have often been studied alone and in only one body  uid. Although the synovial joint is usually the focus of most ... the onset of OA. In animals, such an injury can result in OA onset within weeks [2]. As the joint is considered the focus of the pathology, it is important to determine whether analyses of...

Báo cáo y học: "What do we know about communicating risk? A brief review and suggestion for contextualising serious, but rare, risk, and the example of cox-2 selective and non-selective NSAIDs" pot

... for coxibs. We used relativeFigure 4Risk of myopathy, rhabdomyolysis and death from rhabdomyolysis with statins [65]Risk of myopathy, rhabdomyolysis and death from rhabdomyolysis with statins ... adverse events of statins, including rhab-domyolysis and death from rhabdomyolysis [65]. The risk of death from rhabdomyolysis is about 1 in 300,000 a year (Fig-ure 4).3. Risk of cardiac adverse ... benefits of therapy are framed. Hypertensive patientsonly rarely would have refused hypertensive therapy wheninformation about efficacy was presented as relative riskreduction, but refusal rose...

Báo cáo y học: "Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive" pot

... hospitalmanagement. Because of the relevance of inflammatory medi-ators as biomarkers in acute lung injury, we hypothesized that the levels of various cytokines were elevated early during the course of hospitalization ... 7days later. Cytokine levels were profiled using multiplex antibodycoated beads. Inhalation injury was diagnosed by bronchoscopyduring the initial surgery. The number of days on the ventilator,peak ... When any of the other 15 cytokines measured was added to the multiple logis-tic regression, the Wald statistic was not significant for the added cytokine. The other 15 cytokines were therefore...

Báo cáo y học: "Technical Considerations in Decompressive Craniectomy in the Treatment of Traumatic Brain Injury"

... meninges. The method using temporal fascia is similar to the one introduced by Yu et al.32 They separated the temporal deep fascia from the temporal muscle to the zygomatic arch, and then cut the ... vessels as they pass the edge of the dural window (the pillars were made of hemostastic sponge wrapped by absorbable thread), and then the superfi-cial vessels supporting the portion of brain ... from the base backwards along th e zygoma but left the fascia base 1-2 cm long for the blood supply. Finally, they turned the temporal fascia beneath the temporal muscle and sutured it to the...

Báo cáo y học: "Mechanical complications and reconstruction strategies at the site of hip spacer implantation"

... bearing of the operated extremity cannot be tolerated, • the spacer is insufficiently fixated onto the proximal femur, • the size of the spacer head is too small, • large osseous defects of the ... treatment of the infection source by locally reaching high antibiotic levels, (ii) maintance of joint mobility, (iii) limitation of scar formation, (iv) absence of soft tissue contraction (usually ... whether the insertion of a metallic endoskeleton has a negative influence on the pharmacokinetic properties of the spacer. Ex-perimental data have shown that the release of com-mercially-impregnated...

Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx

... wereexclusively heterozygous M/F a t the as1-Cas locus. There-fore, analysis o f their transcripts could have been ratherdifﬁcult because of the occurrence of at least nine differentforms of ... as2-Casoverlap in the same zone of the gel, the as1-Cas composition of each phenotype was analysed by immunostaining afterTable 1. Primers used in the p resent study. Each pair of primersampliﬁes the target ... performed with the t hermostableDNA polymerase of Thermus aquaticus (Taq polymerase)using either a 480 or a 2400 thermal cycler (PerkinElmer),essentially as described [25]. A typical 50-lL reaction1294...

Báo cáo sinh học: " What have we found out about the influenza A (H1N1) 2009 pandemic virus" doc

... received the lower prophylactic dose of the drug. All of these viruses contain the His275Tyr mutation in the neuraminidase protein that is known to confer oseltamivir resistance. Fortunately, there ... this is likely to reflect the absence of sufficient population immunity to drive the selection of variants. Given how easily the influenza virus mutates, it is only a matter of time before ... be relatively minor in humans, possibly because of the relatively low binding affinity of the influenza A (H1N1) 2009 viral HA for human receptors. Human influenza viruses bind their target...

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