... http://arthritis-research.com/content/5/1/25
25
AERD = aspirin-exacerbated respiratory disease; COX = cyclooxygenase; cys-LT = cysteinyl leukotriene; LT = leukotriene; NSAIDs = non-steroidal
anti-inflammatory drugs; PG = prostaglandin.
Available ... inflammatory cells are
increased in the submucosa of aspirin-sensitive asthmat-
Commentary
COX-2: where are we in 2003?
Specific cyclooxygen...
... Med. Sci. 2007, 4
137
tory effect of thioglycoside I (phenyl-1’-thio-β-D
glucopyranoside) on hSGLT2 and thioglycoside VII
(2-hydroxymethyl-phenyl-1’-thio-β-D-galactopyranosi
de) on hSGLT1. Studies ... chemical synthesized [13, 14].
The most commonly used is known as T-1095
(3-(benzofuran-5-yl)-2',6'-dihydroxy-4'-methylpropio-
phenone 2'-O-(6-O-methoxycarbonyl-β-D-...
... [poly(ADP-ribose) polymerase-1] inhibitors kill breast cancer
associated gene-1 and –2 (BRCA1/2) deficient cells with extremely high efficiency while BRCA+/- and
BRCA+/+ cells are relatively ... motifs in the human breast
cancer susceptibility gene brca2. J Biol Chem 1997; 272: 31941-4.
29. Bryant HE, and Helleday T. Poly(ADP-ribose) polymerase
inhibitors as potential chemothera...
... gelatin zymography, and
collagenase activity assays using both SW1353
chondrosarcoma cells and primary human chondrocytes. The
HDAC inhibitors trichostatin A and sodium butyrate potently
inhibit ... assayed using the dimethylmethylene blue
method. Collagen release is shown as at day 14 and was measured
using an assay for hydroxyproline. Viability was assessed by measuring
lactate...
... microscopy localization of the
11beta-hydroxysteroid dehydrogenase type I enzyme in the
rat. Endocrinology 2001, 142:1644-1651.
20. Sun K, Myatt L: Enhancement of glucocorticoid-induced
11beta-hydroxysteroid ... 11beta-hydroxysteroid dehydrogenase type 1 in type 2 dia-
betic myotubes. Eur J Clin Invest 2005, 35:627-634.
18. Hermanowski-Vosatka A, Balkovec JM, Cheng K, Chen HY, Hern-
andez M,...
... efficacy of PPIs and H2RAs in
the primary prevention of clinically relevant endpoints, such as
bleeding and perforated NSAID ulcers, remains unproven.
The discovery of the isoenzymes cyclooxygenase ... endoscopy, surgery
and pathology. Medication use before and during hospitalisa-
tion, as reported by the patient, was verified by reviewing pre-
scription registrations provided by the...
... Interview
Survey (NHIS) approach of disability days and partial days in
bed [33]. Still others have used work loss days and days
worked but with productivity reduced by half or more [34].
Similar subjective ... this year and will fully describe the
findings from the latest meeting.
In capturing work absences due to arthritis, we considered
both full and partial days (that is, days of...
... Crystallography 2007,
40(3):598-599.
12. Lipinski CA, Lombardo F, Dominy BW, Feeney PJ: Experimental and
computational approaches to estimate solubility and permeability in
drug discovery and ... biochemical reactions including
mono- and poly-ADP ribosyl ation (ART and PARP cata-
lyzed), protein deacetylation and ADP-ribose cyclization
[3]. NMPRTase catalyzes the conversion of fre...
... Experimental and Clinical Pharmacology and Tox-
icology, Freiburg, Germany).
Y2 7632, is a well established inhibitor of ROCK in a vari-
ety of systems. This pyridine derivative is the oldest syn-
thesised ... Stark
1
and Eva M Lang*
1
Address:
1
Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Freiburg, Germany and
2
Institute of Experimental and...