... &
Penner-Hahn, J.E. (1998) Characterization of the zinc binding site
in methionine synthase enzymes of Escherichia coli – the role of
zinc in the methylation of homocysteine. J. Am. Chem Soc. 120,
8410–8416.
15. ... to
ligation of the thiol group of coenzyme M. Mutations in
His237 or Cys239, which are proposed to be involved in
ligating zinc, resulted in an over 90...
... allergy.
factors influencing development of the microbiota. Ann Med
1999, 31(4):288-92.
15. Kalliomaki M, Isolauri E: Role of intestinal flora in the develop-
ment of allergy. Curr Opin Allergy Clin ... The role of the intestinal
microflora for the development of the immune system in
early childhood. Eur J Nutr 2002, 41(Suppi 1):I32-7.
18. Penders J, et al.: Molecular finger...
... consequently lead to increasing inter-
est in the role of osteoclasts in local bone erosion that is
driven by the hypothesis that synovial pannus makes use
Review
The role of osteoprotegerin in arthritis
Georg ... the
spreading of inflammatory synovial tissue [8].
Evidence for a pivotal role of osteoclasts in
local bone erosions
Bone erosion requires osteoclasts an...
... an inflammatory challenge by altering
production of proinflammatory and anti-inflammatory cytokines
and may also affect cytokine signaling by a variety of
mechanisms, including induction of SOCS-3 ... whereas in
processes involving innate immunity, anti-inflammatory effects
of leptin are prevalent. However, it is difficult to elucidate the
role, if any, of leptin during inflammat...
... of DYRK1A detected by immuno-
cytochemistry (Fig. 1) indicate that the role of
DYRK1A in development, maturation, aging and
degeneration may vary in different brain structures
and with the types ... observed in rat [16] and mouse
[17] brains. The difference in phosphorylation of
DYRK1A in cell compartments indicates that intra-
cellular trafficking of DYRK1A may be regulate...
... glycosylated proteins of about 50–90 kDa.
The single polypeptide chain of a kininogen contains three
domains resembling family 2 cystatins.
Cystatins competitively inhibit the activity of papain-
like ... second binding loops of cystatin B and
family 2 cystatins and also what residues of this loop in
cystatin A may participate in the interaction.
To elucidate the role of the...
... Tyr. These mutations may
in uence the shape and volume of the acyl binding pocket
and thereby alter the binding mode and affinity of the
enzyme for PAA and derivatives thereof, while maintaining
the ... phenylglycyl- and p-hydroxyphe-
nylglycyl-enzyme of bF24A, as indicated by, respectively, a
twofold and fourfold increased V
s
/V
h
ratiocomparedtothe
wild-type (Table 4). The V
s
/V
h
r...
... carboxyl group of the a-aminoadipoyl- side-chain
of penicillin N (1), with arginines 74 and 75 apparently
playing a less important role in side-chain binding. Taken
together, the results of this ... ternary com-
plex to oxygen binding, thereby initiating catalysis and
ensuring coupling of 2-oxoglutarate conversion to prime
substrate oxidation.
In the case of DAOCS it has been...
... their role in bone metabolism and repair
remains unclear.
Review of the evidence
To determine the role of COX-2 in bone repair, investiga-
tors have studied fracture healing in animal models of
COX-2 ... 17:963-976.
11. Einhorn TA. Do inhibitors of cyclooxygenase-2 impair bone
healing? J Bone Miner Res 2002, 17:977-978.
12. Zhang X, Schwarz EM, Young DA, Puzas JE,...
... occurs at the
β-carbon of the asparagine residue, consequently (by way of
steric hindrance) preventing the interaction of the HIF-α
C-TAD with the cysteine/histidine-rich 1 domain of p300, a
co-activator ... variation in the
relative expression of the PHD isoforms in different cells, with
PHD-2 being the most abundant HIF prolyl hydroxylase.
Specific ‘silencing’ of all three e...