... involvement of the matrix metalloproteases (MMPs) class in the OA process [20]. Collagenase-3 (MMP-13) was demonstrated to play a major role in cartilage degeneration. It is also suggested that another ... respectively. In an inflammatory rat model of arthritis, it was demonstrated that serum HA levels correlated with the degree of synovitis and clinical arthritis [3]. HA plays the key role in ... production independent of its effect on nitric oxide. J Immunol 1999, 162, 3160-3167.3. Björk J, Kleinau S, Tengblad A, Smedegård G. Elevated levels of serum hyaluronate and correlation with...