Báo cáo y học: "The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma" potx
Báo cáo y học: "The identification of allergen proteins in sugar beet (Beta vulgaris) pollen causing occupational allergy in greenhouse" pdf
... assembly, and also bind phosphati-dylinositol-4,5-bisphosphate and poly-proline, thusbeing important in signalling pathways. Profilins arehighly expressed in pollen, but usually act as minor ... islower (25%) and could be improved using another pro-tease, since the sequence contains very few arginine and lysine residues implicating that cleavage with trypsin max-imally can yield six peptides ... proteinswith a prominent role in pollen tube growth and are oftenmajor allergens, typically affecting > 70% of sensitizedpatients [20,25]. The profilins [26] bind to and modulateactin microfilament...
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Báo cáo y học: "α The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis" pot
... celldeath induced by pro-inflammatory cytokines. Finally, Yudoh and colleagues showed that HIF-1α is necessary foranaerobic energy generation and proteoglycan synthesis byarticular chondrocytes, ... expression of VEGF-A via HIF-1. In conclusion, the α-subunit of HIF-1 is stabilized and HIF-1activity is significantly increased in chondrocytes by hypoxic,inflammatory and mechanical stress. Thus, in ... functional inactivation of HIF-1α in thepresence of interleukin-1β resulted in a significantly increasednumber of apoptotic chondrocytes. These in vitro data are in accordance with the in vivo...
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Báo cáo y học: " The role of γδ T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice" pps
... findings are consistent with a role of γδ Tcells in determining the magnitude of the inflammatoryresponse to acute epithelial injury and in maintaining and repairing the epithelial barrier [16]. ... of respiratory system resistance (A; RRS) and respira-tory system dynamic elastance (B; ERS) following intravenous injection of methacholine in wildtype and knockout mice. The val-ues of ... highlyreactive gas implicated in irritant induced asthma. Ourfindings indicate that the response to airway injury withchlorine differs between wild type and γδ T cell deficientmice. Wild type...
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Báo cáo y học: "The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma" potx
... a patient who likelyhas a lymphocytic variant of hypereosinophilic syndromethat resulted in eosinophilic infiltration of the gastroin-testinal tract, sinuses, and airway that contributed tovariable ... identify eosinophilic inflammation.Introduction Eosinophilic gastrointestinal disease (EGID) is character-ized by identification of abnormal eosinophilic infiltra-tion on morphologic evaluation of ... syndrome ( HES) [3]. Wereport the association of eosinophilic gastroenteritis and eosinophilic bronchitis in a young patient with predni-sone-dependent asthma and some features of lymphocy-tic...
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Báo cáo y học: "The identification of unique serum proteins of HIV-1 latently infected long-term non-progressor patients" doc
... of the family of serine/threonine kinases that are integrallyinvolved in key cellular signaling pathways and can phos-phorylate a wide variety of substrates. Not surprisingly,HIV-1 infection ... tumor-suppressorpathway which acts to arrest the cell-cycle at G1/S byinhibiting the binding of cdk4/6 to Cyclin D1 and subse-quently inhibiting the phosphorylation of Rb. In Figure4C, we investigate ... HP1, including its subtypes α, β, and γ,could be involved in the control of various stages of infec-tion. It is possible that the association of this HP1 bindingprotein with varying subtype of...
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Báo cáo y học: "The Syndrome of Frontonasal Dysplasia, Callosal Agenesis, Basal Encephalocele, and Eye Anomalies – Phenotypic and Aetiologica"
... observed in the present condition are embryological related, occurring in the same critical period of time, most likely during the early induction of the forebrain, resulting in anomalies involving ... hallmark of several syndromes involving the frontonasal process that includes: isolated frontonasal dysplasia (MIM 136760 and 305645), acrofrontofacionasal dysostosis 1 (MIM 201180), acrofrontofacionasal ... mutations in humans affect brain development resulting in different pattern of cerebral and facial manifestations ranging from normality to typical HPE phenotype. Penetrance is relatively low....
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Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc
... ma intained by two s ystems. One is de novosynthesis from b uilding blocks, glutamate, cysteine, and glycine, via two ATP-con suming s teps involving c-g lut-amylcysteine synthetase ( cGCS) and ... in both arginine and cysteine. The cysteinesulfhydryls in protamine must form disulfide bond topackage DNA into small sperm head during the maturationprocess. Thus, while cysteine, a building ... meas-uring its enzymatic activity and examining the geneexpression and localization of the protein. Levels of GRactivity, the protein, and the corresponding mRNA werethe highest in epididymis...
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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparentlyplaying a less important role in side-chain binding. Takentogether, the results of this and ... residues in binding the carboxylate linked to the nucleus of penicillin N(Arg160 and Arg162) and the carboxylate of the a-amino-adipoyl side-chain (Arg266). The results for mutation of Arg74 and ... ternary com-plex to oxygen binding, thereby initiating catalysis and ensuring coupling of 2-oxoglutarate conversion to primesubstrate oxidation. In the case of DAOCS it has been previously shown...
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Báo cáo y học: "The prevalence of mental disorders in adults in different level general medical facilities in Kenya: a cross-sectional study" pot
... study and was involved in drafting the manuscript and revisingit critically for intellectual content. LIK participated in acquisition, analysis and interpretation of data and wasinvolved in ... analysis and interpreta-tion of data and was involved in drafting the manuscript.FAO-O participated in acquisition of data and wasinvolved in drafting the manuscript. DAK was involved in acquisition ... clinics in Kenya. In MD thesisNairobi, Kenya: University of Nairobi, Department of Psychiatry;1984. 6. Lipowski ZJ: Psychiatric consultation: concepts and controver-sies. Am J Psychiatry...
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Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc
... activity of a glucocorticoid-regulated inflammatorycyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892.7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam-matory therapy. ... tolerated and equally efficacious in man-aging inflammation. However, whereas the selectivity of this group of compounds might allow inflammation to beinhibited with minimal effects on certain homeostaticmechanisms, ... role in bone metabolism and repairremains unclear.Review of the evidenceTo determine the role of COX-2 in bone repair, investiga-tors have studied fracture healing in animal models of COX-2 inhibition...
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