Báo cáo y học: "Coaggregation of Fc RI with Fc RIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells" ppsx
Báo cáo y học: "Coaggregation of Fc RI with Fc RIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells" ppsx
... of Fc RI with Fc RIIB in Mast Cells — Ekoff et al 95Figure 6 Schematic diagram showing the effect of coengagement of Fc RI with Fc RIIB. Coaggrega-tion of Fc RI with Fc RIIB inhibits degranulation ... coaggregation of Fc RI with Fc RIIB would have an effect on Bim expression. After Fc RI aggregation and coaggregation of Fc RI and Fc RIIB, respectively, the two isoforms of Bim (Bim EL and Bim L) ... with activating receptors bear-ing an ITAM.9The coaggregation results in theOriginal ArticleCoaggregation of Fc RI with Fc RIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members...
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Báo cáo Y học: A complex fruit-specific type-2 ribosome-inactivating protein from elderberry (Sambucus nigra) is correctly processed and assembled in transgenic tobacco plants doc
... activity of abrin, ricin and moddecin [40,41] and a type-2 RIP from Eranthishyemalis [42] conclusive evidence for in planta antiviralactivity of a type-2 RIP has been obtained only for a type-2RIP ... described previously [6].The carbohydrate-binding specificity of the type-2 RIPswas checked by inhibition of agglutination of trypsin-treated rabbit erythrocytes with galactose and fetuin.Therefore ... arelocated in domain 1, and two others (linking Cys147-Cys162 and Cys188-Cys205, respectively) are located in domain 2. The sugar-binding activity of SNA-If relies ontwo carbohydrate-binding sites...
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Báo cáo y học: "MALDI-TOF MS Combined With Magnetic Beads for Detecting Serum Protein Biomarkers and Establishment of Boosting Decision Tree Model for Diagnosis of Colorectal Cancer"
... 4). Protein Fingerprint Analysis of Serum Samples in Patients with CRC and Healthy Controls The protein profile of the serum samples from the 98 patients with CRC and the 80 healthy controls ... may also be involved. In conclusion, MALDI-TOF MS combined with magnetic beads is one useful tool for integrating se-paration and analysis of complex mixtures of pro-teins. With the panel of ... diagnosed according to combined clinical criteria, including Endoscopic examination of the colon, a combination of computed tomography (CT), positron emission tomography (PET), or both, and further...
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Báo cáo y học: "The Diels-Alder-Reaction with inverse-Electron-Demand, a very efficient versatile Click-Reaction Concept for proper Ligation of variable molecular Partners"
... inside of the cyclobutene ring. The presence of a further double bond inside of the cyclohexene ring is not of relevance due to the inactivity of this double bond in the DARinv. The anhydride ... the synthesis of tetrazines aryl substituted featuring –I attributes. The colour change during DARinv of a tetrazine (magenta) to diazine (yellow) under degassing nitrogen occurs rapidly. ... symmetric dienophiles with higher reactivity should be fa-voured. In 1966 Sauer documented a very high dieno-phile activity of double bonds in cyclic ring systems adjoining to the terminal...
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Báo cáo y học: "Why are some children with early onset of asthma getting better over the years" -aneuploid-prostate-cancer-cells-after-tmz-tmz-bioshuttle-treatment.html#post143974
... study includes medical record examination and a ‘spectral analysis’ in remaining and non-remaining cases at the age of ten of asthma symptoms, signs and associated heredity, environmental risk ... moved into the study-area after 1990 were not in- cluded in the study (17). Data of perinatal and obstetric factors as well as some social factors at baseline (1990) were obtained by investigations ... not least in primary health care. But constitutional factors are plausibly of great im-portance. In the early postnatal stage, obstructive and bronchospastic symptoms typical of asthma may...
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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
... underlying proteinstability at the amino-acid level. The molecular mechanismsunderlying protein maturation, folding, and stability in bacterial cytochromes c are beginning to be understood.Keywords: ... of cytochromes c. It is of interest to characterize cytochrome c with respect to protein maturation, folding, stability, and function using a variety of combined experimental tech-niques. Cytochrome c molecules ... together with theresults from rapidly increasing X-ray crystal and NMRanalyses, have stimulated mutagenesis studies, which con-tribute to the understanding of the mechanisms underlyingprotein maturation,...
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Báo cáo Y học: Hemocyanin from the keyhole limpet Megathura crenulata (KLH) carries a novel type of N-glycans with Gal(b1–6)Man-motifs doc
... overview of the complexity of KLHglycosylation, intact glycoprotein was subjected to automa-ted hydrazinolysis. Resulting glycans were pyridylaminated and analyzed by on-line ESI-MS. Both monitoring ... using similar conditions.Pyridylamination of oligosaccharidesChemically and enzymatically released oligosaccharideswere pyridylaminated according to Kuraya et al.[37].Excess 2-aminopyridine ... Kuraya, N. & Hase, S. (1992) Release of O-linked sugar chainsfrom glycoproteins with anhydrous hydrazine and pyridylamina-tion of the sugar chains with improved reaction conditions. J.Biochem....
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Báo cáo Y học: Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin a-sarcin potx
... ribotoxins.Keywords: Aspergillus protein; cytotoxin; protein –lipidinteraction; ribotoxin; a-sarcin.a-Sarcin is the best characterized member of a family of fungal cytotoxic ribosome-inactivating ... one of the best characterized members of a family of fungal ribotoxins. This proteininduces apoptosis in tumour cells due to its highly specificactivity on ribosomes. Fungal ribotoxins display ... donor-to-acceptor,[N-(7-nitro-2-1,3-benzoxadiazol-4-yl)-dimyristoylglycero-phosphoethanolamine (Nbd-Myr2GroP Etn) and N-(lissaminerhodamine B sulfonyl)-diacylglycerophosphoethanolamine(rhodamine-GroP Etn), respectively, fluorescence energytransfer...
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Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps
... Uversky,Gillespie and Fink [8], Fink [9], and Dyson and Wright [10],who call such proteins 'natively unfolded' or 'intrinsicallyunstructured'.To develop software capable of ... predictor. These predictors use a variety of input attributes including coordination number, net charge,hydropathy, and the presence of particular combinations of amino acids. The false positive error ... progenitorscapable of efficient, high-affinity binding to disordered deter-minants are few. Instead, there are many B cells that bind with low affinity to these determinants, a binding which is insuffi-cient...
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Báo cáo y học: "THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis" pps
... sections stained with hematoxylin and eosin as previously described [24], using the followingscale: 0, normal synovium; 1, synovial membrane hypertrophy and cell infiltrates; 2, pannus and cartilage ... 3b).As inflammatory cytokines are thought to play a critical role in the pathogenesis of RA, we monitored the production of theproinfammatory cytokines TNF-α, IL-1β, and INF-γ as well asanti-inflammatory ... majorerosions of cartilage and subchondral bone; and 4, loss of joint integrity and ankylosis. The assessment was performedby two independent investigators who were blinded to theidentity of the specimens,...
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