Báo cáo y học: "To the Editor: We have diagnosed a patient from Quebec" ppsx
Báo cáo y học: "To the Editor: We have diagnosed a patient from Quebec" ppsx
... what isbeing called the “French-Canadian AID mutation.” The patient was referred to our clinic at the ageof 16 years. He had had chronic cervical lym-phadenopathy since the age of 2 years and ... grand-mother were sisters. Examination revealed normalheight and weight, cervical lymphadenopathy, a left middle-ear effusion, and bilateral lower-lobeexpiratory crackles. A chest radiograph ... happened to carry the rareallele. If the new population remains isolated as itexpands, as has been the case in parts of Quebec,and especially if there is inbreeding, as was the casein this patient s...
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Báo cáo y học: "Immunocytokines: the long awaited therapeutic magic bullet in rheumatoid arthritis" ppsx
... IL-10. Theyshowed the accumulation of this fusion protein at the site ofinflammation, good therapeutic efficacy and a safety profilethat provides the basis for the first clinical trial of antibody-based ... antibody-based pharmacodelivery of DEKAVIL in rheumatoid arthritis(RA) patientsIn general, immunocytokines are scFv fragments of a mono-clonal antibody directed against a specific target fused ... immunohistochemical stainingof synovial tissue of several antibodies directed againstdifferent ECM antigens, and identified EDA, a splice variant offibronectin, as the best candidate. They showed a therapeuticeffect...
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Báo cáo y học: "Long-term benefits of omalizumab in a patient with severe non-allergic asthma" ppt
... safety profile [3-5].Actually, as set by the European Medicine Agency(EMA) [6] and GINA Guidelines [7], in Europe omalizu-mab is indicated as an add-on therapy aimed at improv-ing asthma ... published. Allauthors read and approved the final manuscript.Authors’ information The Centre the authors belong to participated in the last InternationalClinical Trial on omalizumab (CIGE02 5A2 425) as ... nocturnal awakenings (2-3 per night) anddaily use of a lbuterol as rescue medication (3-4 times/day) with side effects related to inhaled steroid (oralcandidiasis) and LABA (tachycardia) that had...
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Báo cáo y học: "Chemical restraint in routine clinical practice: a report from a general hospital psychiatric ward in Greece" ppsx
... in Psychiatry and Psychotherapy Darmstadt,Germany: Steinkopff; 2009, [in German].10. Keski-Valkama A, Sailas E, Eronen M, Koivisto AM, Lonnqvist J, Kaltiala-Heino R: A 15-year national follow-up. ... A total of 14 patients (58.3%) were maleand the age range of the patients wa s between 25 and75 years (mean 46.9 years). Regarding diagnosis, 16patients (66.7%) suffered from schizophrenia ... list of author information is available at the end of the articleBilanakis et al. Annals of General Psychiatry 2011, 10:4http://www.annals-general-psychiatry.com/content/10/1/4© 2011 Bilanakis...
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báo cáo khoa học: "Understanding the implementation of evidencebased care: A structural network approach" ppsx
... [8].Physicians may also i nfluence each other as theyobserve and compare the care provided to their patientsby other physicians, even if they have no direct commu-nication with the other physician. ... provider they have heard about from other patients in the same clinic whentheir primary care provider is not available. The nodestrength serves as a measure of the popularity of the provider type ... knowledge area [9]. The ‘sharing of care’ between two physicians creates a link or a connection. Physicians who share the care ofmany patients have stronger linkages than with physi-cians whom they...
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Báo cáo y học: "Administering the MADRS by telephone or face-to-face: a validity study" docx
... administered the MADRS. A few days later the MADRS wasadministered again, but now by telephone and by a different interviewer. The validity of the telephone rating was calculated through the appropriate ... objective was to study the validityof the observation item, 'apparent sadness'.MethodsResearch design The present study was a validity study among primary carepatients suffering from ... compensate for a possible memory effect.Results were obtained over the full scale and over item 2to 10 as the total variability and the percentage of the totalvariability attributable to each variance...
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Báo cáo y học: "Schizophrenia pathophysiology: are we any closer to a complete model" pps
... in the population and, when expressed individu-ally, may have a relatively weak effect; however, they caninteract synergistically when expressed together. From thisobservation, it has been theorized ... cerebellum as well as a lack of deactivation of the superior temporal cortex [15]. A study by Barch and Csernansky found that there was a similar level of activation in several regions of the brainfor ... during lateadolescence and early adulthood, because this is the period of increased myelination of the perforant pathway[6]. This pathway carries fibers from the entorhinal cortexto the hippocampus...
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Báo cáo y học: "To keep the catch – that is the question: a personal account of the 3rd Annual EULAR Congress, Stockholm" potx
... session to attend, and I heard some friendssaying that a dominating feeling after the Congress wasregret at all the sessions one had been unable to take in.Is there a way out from this dilemma? One ... experience as I see it. The average quality of the posters was distinctly better thanlast year’s, and the selecting committees had more sub-missions from which to choose. Importantly, the midday,manned, ... Diseases, the official EULAR journal. This nowhas an impact factor of over 3 and is next only to the ACRjournal Arthritis and Rheumatism in its field. The submis-sion rate to the Annals is increasing...
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Báo cáo y học: "Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion" potx
... probablycritical for the organization as well as the structural andfunctional integrity of the synovial lining layer. Yet the molecular basis for these interactions is not known. The recent identification ... (VCAM-1) areexpressed by FLSs and synovial macrophages, providing a means for mediating cellular interactions within the synovial lining layer [18].In the context of inflammatory arthritis, the ... molecule. Calcium binding to the cadherins provides the structural rigidity of the fiveextracellular domains that emanate from the plasmamembrane and form stable molecular interactions withcadherins...
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Báo cáo y học: " High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis" pot
... Kitamura H, Iwakabe K, Yahata T, Nishimura S, Ohta A, Ohmi Y, Sato M, Takeda K, Okumura K, Van Kaer L, Kawano T, TaniguchiM, Nishimura T: The natural killer T (NKT) cell ligand alpha-galactosylceramide ... Yoshitomi H, Sakaguchi N, Kobayashi K, Brown GD, Tagami T,Sakihama T, Hirota K, Tanaka S, Nomura T, Miki I, Gordon S, AkiraS, Nakamura T, Sakaguchi S: A role for fungal {beta}-glucansand their ... (RA) and have been linked to a spontaneousmutation in the ZAP-70 signal transduction molecule. Here we hypothesize that similar mechanisms also drive RA, associated withan abnormal innate and...
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