... extracellularlyas a ligand that either acts as a juxtacrine factor ormediates transactivation of a distant unknown recep-tor. Ectodomain cleavage would terminate RING-med-iated ubiquitination ... surface targeted to theinner nuclear membrane. J Cell Biol 180, 763–769.51 Isokane M, Hieda M, Hirakawa S, Shudou M,Nakashiro K, Hashimoto K, Hamakawa H &Higashiyama S (2008) Plasma -membrane- anchoredgrowth ... prolifer-ation, differentiation, angiogenesis and apoptosisthrough the ability of its isoforms to initiate key sig-naling cascades at the plasma membrane (PM) [41].Upon stimulation, PKCa and PKCbII...