... Werner Mayet41Department of Medicine, University of Mainz, Mainz, Germany2Institute of Pathology, University of Mainz, Mainz, Germany3Institute of Pathology, Professional Associations Hospital, ... of cells positive; +, between 5% and 30% of cells positive; ++, between 30 and 60% of cells positive; +++, > 60% of cells positive.Research articleProteinase-3 as the major autoantigen of ... involvement from the Institute of Pathology,University of Bochum/Clinic Bergmannsheil. All of thesepatients had a c-ANCA titer of more than 1:160 (indirectimmunofluorescence on alcohol-fixed...