... epitopes and signaling mechanisms thatcontrol tumor cell and cardiomyocyte viability, butalso to exploit this epitope as a novel potential thera-peutic target to mitigate anti -ErbB2- associated cardio-toxicity ... ELISAs[11], all of the available mAbs against ErbB2, such asHerceptin (trastuzumab), 2c4 (pertuzumab), 7c2, andMAB74, recognize different epitopes from that ofEDIAs.The apparent binding affinity ... (Qiagen, Valencia, CA, USA), and HRP-conju-gated goat anti- [human (affinity-isolated) IgG1] (Fc-specific)(Sigma, St Louis, MO, USA). Erb-hcAb was prepared aspreviously described [9]. N-28 was a generous...