Báo cáo khoa học: "Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity" doc

... biological effects on natural killer cells [13], hematopoietic stem cells [6], endothelial cells [11], and DCs [10]. Although the effects of fucoidan on the mobilization of HPCs in bone marrow ... radioprotection Introduction Bone marrow contains a variety of cells that are required to maintain the hematopoietic and immune systems. On exposure to ionizing radiation, bone marrow is profoundly ... the process. And also, there is another possibility that fucoidan may induce the cell death of some specific cell types whereas it enhances the survival of other cell types of BMCs. The effects...

Báo cáo khoa học: "Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells" pdf

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Báo cáo khoa học: Relaxin-3⁄ insulin-like peptide 7, a neuropeptide involved in the stress response and food intake Masaki Tanaka pptx

... in neurons of the nucleus incertus of the dorsal pons, and a few other regions of the brain-stem. On the other hand, relaxin-3-expressing nerve ﬁbers and the relaxin-3receptors, RXFP3 and RXFP1, ... distribution, predominantly in neurons of the NI, the function of this peptide has been assessed basedupon anatomical studies of the NI at the neuronal level[14,15]. The NI is composed of two ... relaxin-3in the brain, and particularly its functions, including the stress response and food intake, are described.Expression of relaxin-3 in the brainRelaxin-3 neurons in the brainExamination of...

Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx

... N10 and E97 of the secondsubunit. The backbone NH group of R98 forms ahydrogen bond with the backbone CO of F102. Fur-thermore, the orientation of the side chain of the tworesidues brings the ... interaction (Fig. 9B) [49]. The above discussion rationalizes the observed effects of the Y74W mutation in PfTIM on the stability of the dimeric structure and catalytic activity. Examination of the ... at13.9 mL, the position corresponding to the dimer, evenat the lowest concentration studied. Inspection of the gel ﬁltration proﬁle in Fig. 3 shows that the peak corre-sponding to the monomeric...

Tài liệu Báo cáo khoa học: Antimicrobial effects of H4-(86–100), histogranin and related compounds – possible involvement of DNA gyrase ppt

... 4). The bactericidal effects of H4-(86–100) and ciproﬂoxacinwere completed within 30 min, as incubation of the cells for a longer period (2 h) in the presence of increasing concentrations of the ... evaluate the rapidity of action of his-tone H4 peptides and compare it with that of the quinolone antibiotic ciproﬂoxacin, the LD50values of Fig. 2. ATP potentiation of the bactericidalactivity of ... as the number of CFUv of HN-like compound-treated cells ⁄ number of CFUv of control cells. The virtual50% and 90% lethal doses (vLD50 and vLD90) werereported as the compound concentrations...

Tài liệu Báo cáo khoa học: Differential effects of Mxi1-SRa and Mxi1-SRb in Myc antagonism ppt

... [23] and the Bcl2 families [24]. On the molecular level, we show that the uniquePRD on Mxi1-SRa contributes to the differential func-tions of Mxi1-SRa and Mxi1-SRb in Myc antagonism.Deletion of ... Mxi1-SRb, and to assess the transcriptional effects of these isoforms on thesetargets. A better molecular grasp on these Mxi1 iso-forms is necessary for understanding the precise role(s) of Mxi1 ... termini,whereas the FLAG-tagged isoforms carry the tag on their NH2 ter-mini. (B) U2OS cells were transfected with the Myc-tagged con-structs indicated on the left, and the introduced Mxi1 isoformswere...

Tài liệu Báo cáo khoa học: Inhibitory effects of nontoxic protein volvatoxin A1 on pore-forming cardiotoxic protein volvatoxin A2 by interaction with amphipathic a-helix doc

... bind to the membrane of cells.Inhibitory effects of VVA1 on the hemolytic and cytotoxic activity of VVA2 The effects of VVA1 on the hemolytic activity of VVA2 were studied by incubation of human ... phenomenon requires furtherinvestigation [1]. On the basis of the present ﬁndings, we propose thatone molecule of VVA1 interacts with two molecules of VVA2 and thus inhibits the formation of the ... oligomerization of VVA2. Extendingthese results, we hypothesized that the inhibition of VVA2 cytotoxic pore formation by VVA1 can onlyoccur at the ideal ratio of 2 : 1 or lower, due to the ability of one...

Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx

... double-emission monochro-mator, and Glan-Thompson polarizers using quartz cuvetteswith continuous stirring of the suspension, bandwidths of 2 nm for excitation and 4 nm for emission, and excitation and ... different types of cell, including animal, bacterial and fungal. The aim of this study was toobtain information on the cell targets and the mechanism of action of vis-cotoxin isoform A3(VtA3). ... cell death in human lymphocytes, and induce the genera-tion of H2O2in spores [9,15–18].In this work we have gained more information on the cellular targets and the mechanism of action of...

Tài liệu Báo cáo khoa học: Functional effects of deleting the coiled-coil motif in Escherichia coli elongation factor Ts pptx

... show the positions of the protruding coiled-coil motif (residues 187–226) and the C-terminal module. The terminal positions of the deletion of the coiled-coil motif and the insertion of the linker ... for the analysis to ensure that the concentrations of ligandswere maintained at a constant level during migration of the elongation factors, thereby favouring equilibriumconditions. The concentration ... indicate that the maximal rate of the mutantEF-Ts in protein synthesis in vivo is  70%ofthatofthewild-type EF-Ts. The studies of the effect of the EF-Ts mutation understarvation conditions suggest...

Báo cáo khoa học: Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E2 release docx

... differentmechanisms of stimulation w ere u sed in each of the studies, and this alone could account for any differen ces. Further-more, inspection of our current data on the repression of both PGE2release and ... inhibition must be inoperation to account for the full repression of COX-2 and COX/PGES activities in these cells.By contrast, the inhibition of NF-jB-dependent tran-scription by high c oncentrations ... antag-onism of the dexamethasone-dependent repression whenusing RU486 at 10 lM[25]. In an attempt to reconcile the apparent differences between the r esults of these reports and those of the...

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