Báo cáo khoa học: "Radiographic and computed tomographic evaluation of experimentally induced lung aspiration sites in dogs" pot

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Báo cáo khoa học: ERK and cell death: Mechanisms of ERK-induced cell death – apoptosis, autophagy and senescence doc

... markers of autophagy, such as induction of LC3 and conversion of LC3-I to LC3-II [48,49,118],induction of beclin 1 [48], induction of BNIP-3 [66] and activation of G-interacting protein (GAIP) ... evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptorsignalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug -induced apoptosis. ... inhibitor, U0126, attenuates cisplatin- induced renal injury by decreasing in ammation and apoptosis. Kidney Int 67, 458–466.29 Basu A & Tu H (2005) Activation of ERK duringDNA damage-induced...

Báo cáo khoa học: "Stomatal and non stomatal limitation of photosynthesis by leaf water deficits in three oak species: a comparison of gas exchange and chlorophyll a fluorescence data" potx

... whenψwp attained ≈ -3.0 MPa in Q petraea, and ≈ -4.0 MPa in Q pubescens and Q ilex.During drought, A and g decreased in parallel, which led to a linear relationship and ... foran increase of the instantaneous wateruse efficiency during drought progression in Q pubescens and Q ilex, and instanta-neous water use efficiency was higher in Q ilex ... in 7-I plastic pots on a 1:1 (v/v) mixture of brownpeat and sandy soil, in a naturally illuminatedgreenhouse; they were fertilised 4 times a yearduring the growing...

Tài liệu Báo cáo khoa học: Molecular and cellular speciﬁcity of post-translational aminoacyl isomerization in the crustacean hyperglycaemic hormone family docx

... (G) Sinus gland axonal arborizationscontainingD-Trp4 VIH (green) and D-Phe3 CHH (red). (H) Enlargement of axon terminals in the sinus gland with labelling as in (G).Peptidyl isomerization in ... (made in rat) and gp-anti-dW4 (produced in guineapig), two antisera discriminating CHH isomers (gp-anti-pQlmade in guinea pig and rb-anti- pQd in rabbit) [38] and anantiserum raised against ... chirality of a single aminoacyl resi-due within a peptide chain is a subtle and intriguingmechanism that remains poorly known to date, and which leads to structural and functional diversiﬁcationof...

Tài liệu Báo cáo khoa học: Structural and functional speciﬁcities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family docx

... cells, indicating the possibility of PDGF-D ⁄ PDGFR-b constituting an autocrine loop, and PDGF-B acting in a paracrine manner to promoteproliferation and migration of mesangial and intersti-tial ... area containingthe insert of three residues between con-served cysteines III and IV in both PDGF-C and -D, and that PDGF-D is missing the con-served cysteine V. (D) Sequence alignment of PDGF ... detected in the muscle layers of both ciliar body and iris, and throughout the epithelial layers. Interestingly,PDGFR-b is also expressed in the iris, indicatingpossibilities of both autocrine and...

Báo cáo khoa học: Energetic and metabolic transient response of Saccharomyces cerevisiae to benzoic acid docx

... decrease in O2concentration in both the gas and liquid phases and the rapid increase in CO2concentration in both phases following theshift in benzoic acid concentration reﬂect a rapidincrease in ... the presence of benzoic acid introducesan independent ATP drain in cell metabolism may alsobe of interest to those studying the regulation of cellenergetics and metabolism. It offers the possibility ... areaverages of six independent samples, each of whichwas measured in duplicate. The calculated standarddeviations of $ 5% indicate the quality of the sample-processing method and the analysis. In the...

Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt

... (1984) Proteins of myelin. In Myelin,2nd edn (Morell, P., ed.), pp. 197–224. Plenum Press, New York.31. Smith, R. (1992) The basic protein of CNS myelin: its structure and ligand binding. J. Ne ... MBP(74–85) epitope in the N-terminus could increasethe b inding and afﬁnity for I-Aubecause o f occupation of the P1 pocket.Recent thermodynamic a nd kinetic studies of the b inding of TCRs to peptide–MHC ... the side chain of Arg78. The side chain of Arg78 is lesswell deﬁned, as in the case of aqueous solution, because of the absence of interactions with the s ide chains of A sp81 (in the agonist...

Báo cáo khoa học: Covalent and three-dimensional structure of the cyclodextrinase from Flavobacterium sp. no. 92 pdf

... domainB (indicated in Fig. 2). This inserted domain participates in substrate binding and is rather variable. It is considered toplay a role in determining the enzyme speciﬁcity [41]. Theend of ... Theremoval of Ca-I was shown to promote proteolysis [43,44].Ca-I is co-ordinated by the side chains of Asp280 and Ser222 at the beginning and end of domain B as well as bythe main-chain oxygens of ... region in a superposition of CDase (blue with light green domain B) with the TVA-II dimer (grey with dark green domain B and pink N-terminal domain). The N-terminal domain of the other subunit of...

Báo cáo khoa học: Stability and ﬁbril formation properties of human and ﬁsh transthyretin, and of the Escherichia coli transthyretin-related protein potx

... to the retinol-binding protein when it is loaded with retinol [1]. TTRis mainly expressed in the adult liver, the choroidplexus of the brain, and the retina [2,3]. TTR isinvolved in three ... pro-lines and alanines [46,47], and increased hydrogenbonding of the polypeptide chain [48–50]. In addition,improved intersubunit contacts within oligomeric pro-teins contribute to protein stability ... be the Tm of the protein. Theseﬁbrils are amyloidogenic, as determined from theirtinctorial properties in the ThT-binding and CR-bind-ing assays. hTTR and sbTTR could also be induced toform...

Báo cáo khoa học: Substrate and inhibitor speciﬁcity of Mycobacterium avium dihydrofolate reductase pptx

... importance of D31 and L32as substrate-binding, cofactor-binding and inhibitor-binding sites. The objectives of this study were to: (a) utilize site-directed mutagenesis to modify Asp31 and Leu32 ... of aspartate 27 of dihydrofolate reductasefrom Escherichia coli in interconversion of active and inactive enzyme conformers and binding of NADPH.J Biol Chem 265, 5579–5584.19 Birdsall B, Andrews ... enzyme in the folate biosyn-thetic pathway. Information regarding key residues in the dihydrofolate-binding site of Mycobacterium avium dihydrofolate reductase is lacking. Onthe basis of previous...

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