Báo cáo khoa học: " Pharmacokinetics and dosage regimen of ceftriaxone in E coli lipopolysaccharide induced fever in buffalo calves" pot

Báo cáo khoa học: " Pharmacokinetics and dosage regimen of ceftriaxone in E. coli lipopolysaccharide induced fever in buffalo calves" pot

... available about the influence of fever on the pharmacokinetics of cephalosporins. [1,5,16,19].Since there is no information available on the pharmacokinetics and dosage regimen of ceftriaxone in febrile ... objective of the present study was todetermine a satisfactory dosage regimen in febrile buffalo calves. It is not axiomatic to compute the dosage regimen of ceftriaxone to be used effectively in clinical ... optimal dosage regimen of ceftriaxone in buffalo calves.Materials and MethodsThe experiment was performed in five healthy male buffalo calves of 10-12 months age and weighing anaverage weight of...

Báo cáo khoa học: Characterization and cDNA cloning of a cloﬁbrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster potx

... onchromosome 2R. Only two nucleotide differences, whichdo not affect the deduced amino acid sequence, existbetween the sequences of DmEH and jheh2, indicatingthat these two are the same gene. Three ... possibleEH-encoding genes, designated jheh1, jheh2,andjheh3are located between 55F7 and 55F8 on chromosome 2R.The deduced amino acid sequences of all three genes werecompared with those of two ... Based on the occurrence of multiple copies of PPRE- and ARE-like sequences in the promoter regions of these three EH genes, they are probably regulated by manydifferent xenobiotics.AcknowledgementsWe...

Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt

... binding sites and their related potency to stimulate adenylate cyclase and phospholipase C in CHO cells expressingthe human NK-1 receptor. All experiments have been performed in triplicate in ... increase peptide stability at the expense of aminimal decrease in its activity.HGly (named by the authors b-alanine) has beenpreviously introduced in the sequence of the C-terminalheptapeptide of ... the NK-1 receptor.Gly9 in the sequence of SP constitutes a hinge betweenthe helical domain and the C-terminal residues which adoptmore or less extended conformations, Phe7, Phe8, Leu10,and...

Báo cáo khoa học: " Pharmacokinetics and bioavailability of doxycycline in ostriches (Struthio camelus) at two different dose rates" potx

... ...

Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt

... anionicity of their nonbridging oxygens.Sulfonamide-linked nucleosides were employed ﬁrst in antisense technology, where they were found to behighly soluble, and resistant to both enzyme-catalyzed and ... http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms(Received 17 September 2010, revised29 November 2010, accepted 1 December2010)doi:10.1111/j.1742-4658.2010.07976.xMolecular probes are useful ... Closeinspection shows that the relevant subsite of RNase Ahas a negative potential and hence cannot accommo-date an electronegative atom. In contrast, the exocyclicN6-amino group of adenine...

Tài liệu Báo cáo khoa học: Active and regulatory sites of cytosolic 5¢-nucleotidase doc

... site,even though only the amino acid residues involved in the binding of the purine base were identiﬁed, whilethe ribose moiety was completely disordered [11].Mutation of two residues involved in ... Variation of the protein molecular mass in the presence of speciﬁc effectors as estimated by the ratio of the scattered lightintensity. Values are means ± SD of at least three measurements.Sample RatioacN-II ... 8, and the enzyme concentra-tion ranged between 0.09 and 0.14 mgÆmL)1. Scatteringintensities were compared between samples that had thesame protein concentration and refractive index. Underthese...

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... present in the human genome. A recentstudy identiﬁed this homologue as a gene potentiallyinvolved in the development of ovarian cancer. In agenome-wide screening for differently methylated ... poorlycharacterized. Sequence analysis of a wide range of species indicates that HPRT have eleven completelyconserved amino acids, whereas PRTFDC1 genes donot show full conservation of these eleven residues[10,11]. ... reportedDTaggrepresents the calculated difference between Tagg in the presence of compound to be tested and a control condi-tion without compound.Enzyme activities were determined by initial velocitymeasurements...

Tài liệu Báo cáo khoa học: Isolation and molecular characterization of a novel D-hydantoinase from Jannaschia sp. CCS1 docx

... better per-formance of the enzyme, a binding pocket of appropri-ate size is necessary. We then replaced the threeresidues with a range of amino acids using site-directedsaturated mutagenesis, ... analysis were performed usingT-COFFEE [44].Docking simulation of substrate on the active site of HYDJsThe substrate binding pockets of HYDJs and the mode of interaction between substrate and enzyme ... Kinetic parameters for HYDJs and HYDBpwith D,L-p-HPHas the substrate. Parameters were calculated by the Eadie–Hofsteemethod. Values are the mean ± SD of three independent experi-ments.Enzyme...

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of ﬂavoproteins: electron transfer through the nitric oxide synthase ﬂavoprotein domain pdf

... N et al. (2004) Role of the C-terminaltyrosine of ferredoxin–nicotinamide adenine dinucleo-tide phosphate reductase in the electron transferprocesses with its protein partners ferredoxin and flavodoxin. ... the element is inferred from deletion mutants,therefore the effects reported in the table are the opposite of the observed effects.dAll but one report indicate decreased cytochrome creduction ... autoinhibitory insert elements, or elsewhere in the enzyme.Changing the set point for KeqA may in uenceelectron flux through the NOS flavoprotein in interest-ing ways (Fig. 6). For example,...

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of ﬂavoproteins: probes of hydrogen tunnelling pptx

... theH transfer have been shown to exhibit a signiﬁcant pres-sure-dependence of both rate and KIE [57]. Thus, in principle, the pressure-dependence of an isotope effectprovides an excellent method ... plots. We have also plotted (C) the com-bined pressure and temperature dependence of the observed KIEon hydride transfer during the reductive half reaction of morphinonereductase. The data are taken ... aside, we have recently investigated the effect of incomplete coenzyme ⁄ substrate deuteration on theobserved KIE measured using stopped-ﬂow methods[39]. We found that, if there is a reversible...

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