... published risk prediction models,we have analyzed the correlation between V10 and V12Gy and the increased risk of brain necrosis. Volumeswere divided in intervals determined by quantiles and the risk ... the 90thper-centile the risk of radionecrosis was 62%. The actuarial risk at 1 year for the development of brain radionecrosiswas 0% in Q1, 16% in Q2, 24% in Q3, and 51% for V12Gy (Figure 2).Salvage ... employed for the ra diosurgical treat-ment of brain metastases, r adionecrosis has beenreported in up to 50% of treated lesions, with radiationdose, tumor volume and location of the lesion being the most...