... prevent the inactivation. This is in good accord withthe independence of the inactivation on the presence of oxygen.The dihydrolipoate-mediated inactivation of E1 at lowNAD+concentrations is ... under conditions of an increasedsteady-state concentration of dihydrolipoate may providea dual positive effect: relief of the pro-oxidant action of dihydrolipoate on E1 and scavenging of ROS ... Janin, J. (1997) Kinetics of protein-protein recognition. Proteins28, 153–161.54. Hanine, L.C., El Conte, D., Jacquot, J P. & Houee-Levin, C.(2000) Redox properties of protein disulfide bond...