... (USA).
Determination of Roxithromycin by Liquid Chromatography /Mass Spectrometry after
Multiple-Dose Oral Administration in Broilers
Jong-hwan Lim, Byung-kwon Park and Hyo -in Yun*
Division of Veterinary ... Determination of Roxithromycin by Liquid Chromatography /Mass Spectrometry after Multiple-Dose Oral Administration in Broilers 39
difficult t...
... cell lines of diverse histogenetic origin. The median signal of binding of the fluorescent probe is given
as extent of carbohydrate-ligand-dependent binding by subtracting carbohydrate-independent ... moiety of the a1–6 arm is emphasized
by introducing the term ÔbackfoldedÕ into the figure (C; also Fig. 7C,D).
Fig. 6. Analysis of the involvement of the bisecting GlcNAc unit...
... (A) Interaction of the peptide substrate
PQGLAG containing a P
1
¢ Leu with the MMP-7 binding site. (B)
Interaction of the peptide substrate PQGKAG containing a P
1
¢
Lys with the MMP-9 binding ... novo sequencing of the nano-
ESI–qTOF and MALDI-TOF ⁄ TOF MS data followed by
database matching (peaks protein id and spider) [86] was
Tropoelastin degradation by elastinolytic MMPs A. He...
... some of the disorder experienced by the nearby
lipids to the motion and tilting of this embedded
segment.
Thinning of the bilayer in the presence of Ab40
Because Ab40 is known to disrupt the integrity ... the unfolding of the
C-terminal, embedded, region of the peptide. As dis-
cussed above, Ab40 is capable of increasing the tilt of
the surrounding lipids, thus disordering...
... functioning of the ubiquitin–proteasome
pathway is essential for the degradation of the major-
ity of intracellular proteins and is implicated in many
cellular processes, including regulation of apoptosis.
Both ... expression of
DR5 plays a critical role in the reactivation of
TRAIL-induced apoptosis after proteasome inhibition
in glioma cells.
CHOP is not involved in DR...
... critical r ole in the regulation of cell
proliferation, including SMC, by inhibiting signalling mol-
ecules [ 45–47]. Caveolin-3 is the main isoform in muscle
cells, including SMC [30]. Caveolin-1 and ... phase.
We examined the effects of PUFA on cyclin D1 by measuring
its concentration in whole cell extracts by using a monoclonal
anti-(cyclin D1) Ig. There was little cyclin D...
... requirement of three. The crystal structures of CTX–
inhibitor complexes gave interesting insights into the binding. Surprisingly,
none of the inhibitors occupied any of the aglycone subsites of the ... bias introduced by a possible shift of
the charge state distribution caused by ligand binding.
The dimeric protein forms were disregarded in the
determination of binding co...
... activation of protein kinase C
(PKC) [9]. Links between retinoids and PKC were con-
vincingly demonstrated [10], and even pointed to direct
binding between PKCs and RA receptors and control
of transcriptional ... IMR-32 cell line was main-
tained in DMEM ⁄ F12 (1 : 1) (Invitrogen, Basel, Switzer-
land), and the murine neuroblastoma N2a and human
embryonic kidney HEK293 cell lines were m...
... DNp63a by
TNF-a was attenuated by inhibition of NF-jB, sug-
gesting that activation of NF-jB may be involved in
the regulation of the degradation of DNp63a. Interest-
ingly, knockdown of DNp63a ... ubiquiti-
nated by immunoprecipitation and western blotting
after transfection of overexpressing Myc-tagged
DNp63a- and HA-ubiquitin-encoding plasmids into
cells (Fig. 1A). Th...
... introduction of charged
molecules into inner parts of the cell membrane from where
these can be overtaken by further binding sites originating
from the cytoplasmic region of the protein. It is tempting ... Ntcp
is a serine/threonine phosphorylated phosphoprotein which
is dephosphorylated by cAMP [22]. Upon phosphorylation
of serine/threonine by a protein kinase A, taurocholate
t...