... 3975–3987 ª 2005 FEBS 3985 of D02 was 4.0 nm and the KD of DNS 9.2 nm, that isdouble that of D02. This larger KDwas accounted for by the twofold larger kd of DNS than that of D02 andtheir nearly ... portions of DNS areimportant for the nuclear import mediated by Trn-1.ResultsDetermination of hnRNP D NLSThe exon 8 of hnRNP D encodes the 21 amino acidssequence common to all the isoforms ... consists of two RNA bindingdomains (RBDs) and has a high content of glycine inthe C-domain, like hnRNP A1 [20,21]. Four isoforms,D01 ⁄ p37, D02 ⁄ p40, D1 ⁄ p42 and D2 ⁄ p45, are formedby...