... Our novel data demonstrate that the )1CfiAmutation at the transcriptional initiation site is causative,which regulates b2GPI gene expression at the transcriptionallevel that ultimately affects ... site. Theseresults also confirm the location of the TFIID consensussequence at the b2GPI transcriptional initiation site, which isdisrupted by the )1CfiA mutation that would ultimatelyaffect the ... 0.0001). Of the 21 individuals with the Trp316Sermutation, 20 had the )1CfiA mutation. On the other hand,of the 16 individuals with the Cys306Gly mutation, only onehad the )1CfiA mutation, strongly...