... near the N- and C-termini of the linkers: this suggests thata mobile connection with both the catalytic domainand the binding module is required for the function of the nanomachine. Furthermore, ... etc.), the pKadifferencebetween heteroatoms is of importance: the smaller thisdifference, the stronger the hydrogen bond, as the hydrogen atom is equally shared between the donorand the acceptor ... domain, with the noticeable exception of the a-amylase from the bacte-rium Pseudoalteromonas haloplanktis, which displaysan additional small (21 kDa) C-terminal domain hav-ing the size of a carbohydrate-binding...