The Biological Sample Classification Using Gene Expression Data
The Biological Sample Classification Using Gene Expression Data
... data. The quality of gene expression data strongly depends on the equiments used, the biological variation and the measurement condition. Therefore, the gene expression data must be pre-processed ... Moreover, the gene expression level is also regulated by the products of other genes. This means that there exists a gene regulatory network by which a gene activities are regulated by others. Therefore, ... contain from 5,000 to 10,000 genes for less than 100 tumor samples. The problem of classifying the biological samples using gene expression data has becomed the key issue in cancer research....
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A gene expression database for the molecular pharmacology of cancer pptx
... gene expression levels. The gene expression profiles show considerable coherence, in thatcells clustered on the basis of their expression profiles for 1,376genes and 40 targets tend to sort themselves ... gene and a drug by taking the (normalized) level of expression of the gene in each cell line, multiplying it by the corresponding (nor-malized) sensitivity of the cell to the drug, summing the ... compounds to the expression patterns of 1,376 genes in the 60 celllines. Included, in addition to the gene expression levels, are data for 40 molec-ular targets assessed one at a time in the cells....
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Báo cáo hóa học: " Research Article The Wavelet-Based Cluster Analysis for Temporal Gene Expression Data" pptx
... it extracts the localized high-frequency details of the expression signal.When the wavelet is fully diluted, the length of the wavelet ismore comparable to the length of the gene expression ... and the calculated CWT coefficients refer to the closeness of the gene expression profile to the wavelet at the current scale. The flexible approach uses a scalable window. The advantages of the ... Figure 1 shows the expression profile variationofthisgeneindifferent experimental conditions. Because the strength of expression of the rpoS gene varies among condi-tions, that is, the expression...
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Báo cáo hóa học: " Research Article Clustering Time-Series Gene Expression Data Using Smoothing Spline Derivatives" pptx
... Heatmap of smoothed gene expression profiles for the whole dataset. Genes are ordered according to their cluster deter-mined by the k-means algorithm. Horizontal blue lines separate the 4 clusters. ... profiles themselves. When colorcoding the profiles themselves, the eye needs to integ rate the changes of colors along the ordered time points to extract the direction and the amplitude of the changes ... smoothed gene expression profiles. The clustering of the gene expression profile deriva-tives was performed as described in the previous paragraphs.Similarly, the hierarchical clustering of the time...
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Báo cáo hóa học: " The Local Maximum Clustering Method and Its Application in Microarray Gene Expression Data Analysis" docx
... to the clusters in the models than the LMC and the hierarchic clus-tering methods.3.2. An application to microarray gene expression data Application of the LMC method to gene expression data ... clustered. The local maximum of a data point i is the data point whose magnitude is the maximumamong all the data points within a certain distance from the data point i. A peak has the maximum ... functionsor to classify samples with similar gene expression profiles.There are several factors that make the clustering of gene expression data different from data clustering in a general60 EURASIP...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... ABPstransduced the changes in cell structure that occur dur-ing morphogenesis to the nucleus, resulting in changesin gene expression via either the nuclear shuttling oftranscription factors or the assembly ... liganded ARto the nucleus. In the nucleus, FLNa(16–24) disruptsinteractions between the N- and C-termini of the AR,and interferes with the binding of the coactivator TIF2[86,91]. There is evidence ... and enhances the ability of Nkx2.5to bind to the NKE (Nkx2.5-binding element) boxes in the ANF promoter. These results suggest that hhLIMpromotes specific expression of the ANF gene bycooperating...
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Neighborhoods and the Health of the Elderly: Challenges in Using National Survey Data pot
... tract. Typically, data sets are only coded with the census tracts of the most recent census data set. In the case of the PSID, for instance, data from the 1970s contained information using 1970 census ... containers in the streets; rating of most of the housing units in the face block; and general rating of the condition of the street. There are also logistical challenges in linking survey data from ... effects exploiting the panel nature of the PSID. Due to the long panel for the PSID (first fielded in 1968), the PSID is the only national data set currently available to study the effects of early-life...
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Báo cáo hóa học: " Research Article Clustering of Gene Expression Data Based on Shape Similarity" potx
... parameter was the maximum value over the numberof trials. The third and fourth criteria made use of the Silhouette statistic, one using the clusters of transformed data and one using the corresponding ... would place these two sequences in differentclusters. By transforming the data, the similarity of the twosequences is enhanced, and the clustering algorithm can thenplace them in the same cluster. ... difference. However, since the gene expres-sion profiles were obscured by the varying levels manifestedin the data, the time difference must be obtained on the expression levels with the same scale and...
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Báo cáo hóa học: " Research Article Inferring Time-Varying Network Topologies from Gene Expression Data" docx
... on original data 14 — —SSM on undersampled data —33SSM on interpolated data —42CoD on original data 12 — —CoD on undersampled data —32CoD on interpolated data —42on whether these frameworks ... the first two regimesfor the genes coclustered in these regimes.To clarify the validity of the presented approach, wepresent a similar analysis on another data set the T-cell ex-pression data ... regime-specific gene expression dynam-ics for that biological process, globally within the cell. Sup-pose there are N genes whose expression is related to a sin-gle process. The ith gene s expression...
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