... pro-TGF-b precursor. Followinghomodimerization, pro-TGF-b is cleaved into two frag-ments: the C-terminal ho modimer corresponds tomature TGF-b, while the N-terminal homodimer islatency-associated ... the pr esence of one or more of IL-1b, IL-6, IL-23, and TGF-b. With IL-2-containing medium provideda baseline for comparison, IL-1b, IL-6, or IL-23, but notTGF-b, could promote the differentiation ... combination ofIL-1b plus IL-6, IL-1b plus IL-23, IL-6 plus IL-23, or IL-1b plus IL-6 plus IL-23, significantly increased the per-centage of Th17 cells at higher extents compared withany single...