... (Table 77 -4) . Older patients and those with a Karnofsky performance status <70 have a poor prognosis unless the poor performance is a reversible consequence of the tumor. Table 77 -4 Karnofsky ... safety and efficacy of particular treatments. 1The AJCC Manual for Staging Cancer, 5th edition, can be obtained from the AJCC at 55 East Erie Street, Chicago, IL, 60611. with the physiologic ... Tumors with higher growth fractions, as assessed by expression of proliferation-related markers such as proliferating cell nuclear antigen (PCNA), behave more aggressively than tumors with lower...