... in PD, and understand-ing its properties and functions will aid in our under-standing of disease pathology and progression.Experimental proceduresChemicals and reagentsAll compounds and proteins ... wild-type and G2019S LRRK2 (datanot shown). A small panel of kinase inhibitors was thenselected for further study (Table 1), and dose–responserelationships were obtained using wild-type (Fig. 6A) and ... bothautophosphorylation and LRRKtide phosphorylation,to determine whether there are any differences. Wild-type and mutant LRRK2 proteins, G2019S, D1994A,R1441C, Y1699C, I1122V, and I2020T, were incubatedwith32P-labeled...