... 4B).On the basis of integration of the anomeric signals, the 4-keto and gem-diol forms of this compound coexist inequilibrium at an approximately 5 : 2 ratio. Fullassignment of the NMR spectra of ... of the corresponding side chain, Arg220, the NADPH cofactor and the substrate analog hexosein the MUR1 structure (Fig. 11). Some of the distancesbetween these groups are rather long for classic ... dimerization of the apoenzyme, and oxidation of the bound NADPH results in dimer dissociation[38].Unlike the case of PBCV-1, where the GMD has ahigher specific activity as a reductase than as a 4,6-de-hydratase,...