... often associated with hemosiderinuria and an
Chapter 101. Hemolytic Anemias and Anemia
Due to Acute Blood Loss
(Part 2)
Table 101- 2 General Features of Hemolytic Disorders
General
examination ... pyknosis and actual loss of the nucleus.
Reticulocytes Increased
Bilirubin Increased (mostly unconjugated)
LDH
Increased (up to 10X normal with...
... Chapter 101. Hemolytic Anemias and Anemia
Due to Acute Blood Loss
(Part 7)
Clinical Presentation and Diagnosis
The spectrum of clinical severity ... prophylaxis postsplenectomy is
controversial.
4. HS patients often may require cholecystectomy. It used to be
considered mandatory to combine this procedure with splenectomy, but this
may not ... HE causing...
...
Extracorpuscular
Factors
Hereditary
Hemoglobinopathies
Familial hemolytic
uremic syndrome (HUS)
Chapter 101. Hemolytic Anemias and Anemia
Due to Acute Blood Loss
(Part 1)
Harrison's ...
of anemia in these two groups of patients are quite different, and they will be
considered separately.
Hemolytic Anemias
Anemias due to increased destr...
... Chapter 101. Hemolytic Anemias and Anemia
Due to Acute Blood Loss
(Part 3)
Figure 101- 1
cause considerable iron loss, needing replacement. With chronic ... needs frequent blood transfusions. Chronic iron overload will cause
secondary hemochromatosis; this will cause damage, particularly to the liver,
eventually leading to cirrhosis, and to the heart...
... instead autosomal recessive (with the
patient being homozygous).
Figure 101- 3
Chapter 101. Hemolytic Anemias and Anemia
Due to Acute Blood Loss
(Part 5)
Hemolytic Anemias Due to Abnormalities ... (including ankyrin and the so-called band
4.1 and band 4 .2), which thus connect these two structures intimately.
Figure 101- 2
Diagram of red c...
... Chapter 101. Hemolytic Anemias and Anemia
Due to Acute Blood Loss
(Part 6)
Peripheral blood smear from patients with membrane-cytoskeleton
abnormalities. A. Hereditary spherocytosis. ... Hereditary elliptocytosis,
heterozygote. C. Elliptocytosis, with both alleles of the α-spectrin gene mutated.
[From L Luzzatto, in J Gribben and D Pravan (eds): Molecular H...
... Chapter 101. Hemolytic Anemias and Anemia
Due to Acute Blood Loss
(Part 8)
Abnormalities of the Glycolytic Pathway
(Fig. 101- 1) Since red cells, in the course ... the jaundice persists and is usually
associated with a very high reticulocytosis. The anemia is of variable severity;
sometimes it is so severe as to require regular blood transfusions; somet...
... directly and via reduced
glutathione (GSH), defends these cells against oxidative stress. G6PD deficiency
is a prime example of an HA due to interaction between an intracorpuscular and an
extracorpuscular ...
G6PD activity in most tissues, this is less marked than in red cells, and it does not
seem to produce symptoms.
Figure 101- 4
Diagram of redox metabolism in the r...
... acute anemia is over, and in the absence of comorbidity, full recovery from
acute HA associated with G6PD deficiency is the rule.
Chapter 101. Hemolytic Anemias and Anemia
Due to Acute Blood ... Mediterranean
Sea, in the Middle East, and in India; G6PD A– in Africa and in Southern Europe;
G6PD Vianchan and G6PD Mahidol in Southeast Asia; G6PD Canton in Chi...
... dish of
fava beans; but
t
rigger can be
Chapter 101. Hemolytic Anemias and Anemia
Due to Acute Blood Loss
(Part 11)
Table 101-
5 Drugs that Carry Risk of Clinical Hemolysis in Persons
with ... history
taking
Favism Acute Destruc
tion of older
fraction of
G6PD-
deficient red
G6PD
assay
Triggere
d by ingestion
of large dish of
fava beans; but
t
rigge...