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Chapter 101 Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 1) pptx

Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 1) pptx

Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 1) pptx

... Extracorpuscular Factors Hereditary Hemoglobinopathies Familial hemolytic uremic syndrome (HUS) Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 1) Harrison's ... of anemia in these two groups of patients are quite different, and they will be considered separately. Hemolytic Anemias Anemias due to increased destruction of red cells, or hemolytic anemias ... Acute Blood Loss (Part 1) Harrison's Internal Medicine > Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss Definitions A finite life span is a distinct characteristic...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 3) pptx

Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 3) pptx

... Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 3) Figure 101- 1 cause considerable iron loss, needing replacement. With chronic ... needs frequent blood transfusions. Chronic iron overload will cause secondary hemochromatosis; this will cause damage, particularly to the liver, eventually leading to cirrhosis, and to the heart ... rather precipitous fall in hemoglobin, an occurrence sometimes referred to as aplastic crisis. Inherited Hemolytic Anemias There are three essential components in the red cell: (1) hemoglobin,...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 13) pptx

Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 13) pptx

... with sepsis or endocarditis from a variety of organisms. Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 13) Pyrimidine 5'-Nucleotidase (P5N) Deficiency ... hemolysis is due to an inherited defect, but this is external to drumming. The other situation, which has been called microangiopathic hemolytic anemia, (Table 101- 6) is chronic and iatrogenic; ... cell enzyme defects (after G6PD deficiency and PK deficiency). The anemia is lifelong, of variable severity, and may benefit from splenectomy. Familial Hemolytic Uremic Syndrome (HUS) This disorder...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 2) docx

Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 2) docx

... often associated with hemosiderinuria and an Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 2) Table 101- 2 General Features of Hemolytic Disorders General examination ... pyknosis and actual loss of the nucleus. Reticulocytes Increased Bilirubin Increased (mostly unconjugated) LDH Increased (up to 10X normal with intravascular hemolysis) Haptoglobin Reduced to ... 5 mM) goes hand in hand with the gradual loss of cellular organelles and of biosynthetic abilities. In the end the erythroid cell undergoes a process that has features of apoptosis, including...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 5) ppt

Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 5) ppt

... instead autosomal recessive (with the patient being homozygous). Figure 101- 3 Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 5) Hemolytic Anemias Due to Abnormalities ... (including ankyrin and the so-called band 4.1 and band 4.2), which thus connect these two structures intimately. Figure 101- 2 Diagram of red cell membrane/cytoskeleton. (For explanation ... glycosylated, and they carry antigenic determinants that correspond to blood groups. Underneath the membrane, and tangential to it, is a network of other proteins that make up the cytoskeleton. The...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 6) doc

Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 6) doc

... Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 6) Peripheral blood smear from patients with membrane-cytoskeleton abnormalities. A. Hereditary spherocytosis. ... Hereditary elliptocytosis, heterozygote. C. Elliptocytosis, with both alleles of the α-spectrin gene mutated. [From L Luzzatto, in J Gribben and D Pravan (eds): Molecular Hematology, 2d edition. ... Hematology, 2d edition. Oxford, Blackwell, 2005; with permission.] Table 101- 3 Inherited Diseases of the Red Cell Membrane-Cytoskeleton Gene Chromosomal Location Protein Produced Disease(s)...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 7) docx

Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 7) docx

... Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 7) Clinical Presentation and Diagnosis The spectrum of clinical severity ... prophylaxis postsplenectomy is controversial. 4. HS patients often may require cholecystectomy. It used to be considered mandatory to combine this procedure with splenectomy, but this may not ... HE causing clinical disease is similar to that of HS. However, an asymptomatic form, referred to as Southeast Asian ovalocytosis, has a frequency of up to 7% in certain populations, presumably...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 8) pdf

Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 8) pdf

... Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 8) Abnormalities of the Glycolytic Pathway (Fig. 101- 1) Since red cells, in the course ... the jaundice persists and is usually associated with a very high reticulocytosis. The anemia is of variable severity; sometimes it is so severe as to require regular blood transfusions; sometimes ... is due to the fact that the anemia is remarkably well-tolerated because the metabolic block at the last step in glycolysis causes an increase in bisphosphoglycerate (or DPG), a major effector...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 9) ppsx

Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 9) ppsx

... directly and via reduced glutathione (GSH), defends these cells against oxidative stress. G6PD deficiency is a prime example of an HA due to interaction between an intracorpuscular and an extracorpuscular ... G6PD activity in most tissues, this is less marked than in red cells, and it does not seem to produce symptoms. Figure 101- 4 Diagram of redox metabolism in the red cell. G6P, glucose 6-phosphate; ... require exchange transfusion; if the anemia is less severe, it may present later in life or may even remain asymptomatic and be detected incidentally when a blood count is done for unrelated...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 10) pps

Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 10) pps

... acute anemia is over, and in the absence of comorbidity, full recovery from acute HA associated with G6PD deficiency is the rule. Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood ... Mediterranean Sea, in the Middle East, and in India; G6PD A– in Africa and in Southern Europe; G6PD Vianchan and G6PD Mahidol in Southeast Asia; G6PD Canton in China; and G6PD Union worldwide. The heterogeneity ... Blood Loss (Part 10) Epidemiology G6PD deficiency is widely distributed in tropical and subtropical parts of the world (Africa, Southern Europe, the Middle East, Southeast Asia, and Oceania)...
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