Chapter 094 Soft Tissue and Bone Sarcomas and Bone Metastases (Part 2) pps
Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 1) pot
... body Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 1) Harrison's Internal Medicine > Chapter 94. Soft Tissue and Bone Sarcomas and Bone Metastases Soft Tissue ... Metastases Soft Tissue and Bone Sarcomas and Bone Metastases: Introduction Sarcomas are rare (<1% of all malignancies) mesenchymal neoplasms that arise in bone and soft tissues. These tumors ... childhood and are the fifth most common cause of cancer deaths in children. Sarcomas may be divided into two groups, those derived from bone and those derived from soft tissues. Soft Tissue Sarcomas...
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 2) pps
... muscles may be present. All new and persistent or growing masses should be biopsied, either by Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 2) Classification Approximately ... mediastinum, and subcutaneous tissue. Rhabdomyosarcomas, Ewing's sarcoma, and other small-cell sarcomas tend to be more aggressive and are more responsive to chemotherapy than other soft tissue sarcomas. ... common site of metastases. Exceptions are GISTs, which metastasize to the liver; myxoid liposarcomas, which seek fatty tissue; and clear-cell sarcomas, which may metastasize to bones. Central...
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 3) ppsx
... leiomyosarcomas. Dacarbazine also has some modest activity. Taxanes have selective activity in angiosarcomas, and vincristine, etoposide, and irinotecan are effective in rhadomyosarcomas and Ewing's ... chemotherapy, with or without other modalities. Surgery Soft tissue sarcomas tend to grow along fascial planes, with the surrounding soft tissues compressed to form a pseudocapsule that gives ... time-consuming, and less expensive. Adjuvant Chemotherapy Chemotherapy is the mainstay of treatment for Ewing's primitive neuroectodermal tumors (PNET) and rhabdomyosarcomas. Meta-analysis of 14 randomized...
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 4) ppsx
... differentiated—low grade Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 4) Bone Sarcomas Incidence and Epidemiology Bone sarcomas are rarer than soft tissue sarcomas; they ... extending into the adjacent soft tissue compartment or into bone) . The tumor node metastasis (TNM) staging system is shown in Table 94-2. Table 94-2 Staging System for Bone Sarcomas Primary tumor ... and osteochondromas can transform into chondrosarcoma; fibrous dysplasia, bone infarcts, and Paget's disease of bone can transform into either malignant fibrous histiocytoma or osteosarcoma....
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 5) pps
... Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 5) Stage Grouping Stage IA T1 N0 M0 G1,2 low grade ... intramedullary and soft tissue extension. A chest radiograph and CT scan are used to detect lung metastases. Metastases to the bony skeleton should be imaged by a bone scan. Almost all osteosarcomas ... appearance), and a cuff of periosteal new bone formation at the margin of the soft tissue mass (Codman's triangle). A CT scan of the primary tumor is best for defining bone destruction and the...
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 6) ppt
... Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 6) Chondrosarcoma Chondrosarcoma, which constitutes ~20–25% of all bone sarcomas, is a tumor of adulthood and old ... Metastatic to Bone Bone is a common site of metastasis for carcinomas of the prostate, breast, lung, kidney, bladder, and thyroid and for lymphomas and sarcomas. Prostate, breast, and lung primaries ... for 80% of all bone metastases. Metastatic tumors of bone are more common than primary bone tumors. Tumors usually spread to bone hematogenously, but local invasion from soft tissue masses...
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Chapter 094. Soft Tissue and Bone Sarcomas and Bone Metastases (Part 7) ppsx
... may relieve pain and inhibit bone resorption, thereby maintaining bone mineral density and reducing risk of fractures in patients with osteolytic metastases from breast cancer and multiple myeloma. ... surgery and post-operative radiotherapy in 300 adults with soft tissue sarcomas. Cancer 47:2391, 1981 [PMID: 7272893] NIH Consensus Development Panel on Limb Sparing Treatment of Adult Soft Tissue ... monitoring of serum electrolytes and creatinine is recommended. Monthly administration prevents bone- related clinical events and may reduce the incidence of bone metastases in [PMID: 2709861]...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 2) pps
... kidney) and tissues (i.e., cornea, eye, skin) are often used to replace damaged tissues. However, the clinical need for transplantable tissues and organs far outweighs the available supply, and ... capacity for Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 2) Strategies for Stem Cell Replacement Stem cell transplantation is not a new concept and it is already ... damaged organ or into the circulation, allowing them to "home" into the damaged tissue; (2) in vitro differentiation of stem cells followed by transplantation into a damaged organ—e.g.,...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 2) ppsx
... Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 2) Aplastic Anemia Definition Aplastic anemia is pancytopenia with bone marrow ... constitutional: the genetic diseases Fanconi's anemia and dyskeratosis congenita, while frequently associated with typical physical anomalies and the development of pancytopenia early in life, ... Sometimes blood count depression is moderate or incomplete, resulting in anemia, leukopenia, and thrombocytopenia in some combination. Aplastic anemia is Pregnancy Idiopathic Cytopenias...
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